A Study on Association between Tp-e/QT Ratio (T peak-end/QT) and In–Hospital Prognosis in Acute ST-Elevation Myocardial Infraction (STEMI) Patients

Sridhar, S (2019) A Study on Association between Tp-e/QT Ratio (T peak-end/QT) and In–Hospital Prognosis in Acute ST-Elevation Myocardial Infraction (STEMI) Patients. Masters thesis, Madurai Medical College, Madurai.

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Abstract

BACKGROUND: Both the Tpeak-Tend interval (Tp-e) and the Tp-e/QT ratio have been linked to increased risk for arrhythmia. Patient Tp-e/QT ratios were investigated prior to primary to thrombolysis with ST-segment elevation myocardial infarction (STEMI). HYPOTHESIS: Tp-e/QT ratio maybe asscioated with the prognosis in patients with ST-segment elevation. METHODS: A total of 100 patients with STEMI admitted in ICCU, Madurai medical college. The Tp-e and Tp-e/QT ratio were determined using electrocardiograms in the subjects exhibiting ST-segment elevation. This is a prospective. Relevant clinical data is collected. QTd and Tp-e/QT ratio (tangent method) is calculated from “at admission ECG” just before thrombolysis. Multivariate logistic regression analysis was done to determine the predictors of in-hospital outcomes. A p-value of < 0.05 is considered statistically significant. RESULTS: 79% Were male and female 21%). Tp-e/QT ratio were 54% were present within the normal ratio of < 0.25. 35% were present in ratio between 0 .25-0.35. There were 11% patients in very high ratio of more than 0.35.Tp-e/QT ratio are found to be independent predictors of in MACE, Ratio was within normal limits in patients presented with anterior wall, posterior wall, anteroseptal and lateral wall MI. 39% met with major adverse cardiac events, out of which maximum number of study population had cardiogenic shock (19%) during hospital stay. 13 patients met with malignant arrhythmic events (ventricular tachycardia and ventricular fibrillation). MACE was highly significant (p < 0.001) with anterolateral wall MI patients. Significant in Infer posterior wall MI (p < 0.008) and Inferior wall MI (p < 0.042). Tp-e/QT ratio is independent predictor of in-hospital mortality in addition to reduced LVEF and AWMI. CONCLUSION: Tp-e/QT ratio may serve as a prognostic predictors of in hospital MACE independently and Tp-e/QT ratio predicts patients with in-hospital all cause mortality in thrombolysed STEMI patients.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Tp-e/QT Ratio, MI, VT/VF, Mace Arrthymias.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 27 Aug 2019 02:42
Last Modified: 31 Aug 2019 15:15
URI: http://repository-tnmgrmu.ac.in/id/eprint/11244

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