Design, Development and Optimization of Controlled Release Tablet of Fluconazole.

Subba Raghavendra Rao, M (2012) Design, Development and Optimization of Controlled Release Tablet of Fluconazole. Masters thesis, KMCH College of Pharmacy, Coiimbatore,Tamil Nadu, India.


Download (2MB) | Preview


The purpose of this research was to prepare controlled release tablets of Fluconazole in reducing the dose and increasing efficiency with reducing fluctuations.By controlling the rate of release the side effects such as hallucinations and paranoid behaviour will also be minimized.A 22 factorial design was employed to optimize the formulations,producing 4 factorial points,this design generally involves dependent variables Y,independent variable X.The independent variable selected for this study were (X1-X4),X1amount of maltodextrin,X2 amount of Carbopol 940, X3 amount of HPMC,X4 amount of Ethyl cellulose.The dependent variable were (Y1-Y4),Y1 hardness,Y2 amount of drug release at 1st hour, Y3 time taken to reach t50%, Y4 Zone of inhibition.Controlled release release tablets have been prepared incorporating antifungal drug Fluconazole using polymers like Maltodextrin,HPMC,Carbopol 940,Ethyl Cellulose.The anti microbial studies showed good antifungal activity based on zone of inhibition.The invitro drug release studies revealed that as the concentration of polymer increased the drug release decreased.Formulations containing higher concentration of polymers were able to efficiently control Fluconazole release over a time period of 8hrs.The formulations containing 2:2 ratio of polymers gave the best results, among which the formulation containing Carbopol-940:HPMC with 2:2 ratio of polymers is concluded as best formulation in terms of required drug release in a controlled release manner. The drug release mechanism was confirmed as case-II transport or typical zero-order release.IR spectra matching confirmed that there was no major interaction between the drug and the excipients used.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Design; Development; Optimization; Tablet; Fluconazole
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 06 Jul 2017 06:00
Last Modified: 06 Jul 2017 06:00

Actions (login required)

View Item View Item