A study of the clinical characteristics, risk factors and mortality outcomes of patients admitted with acute decompensated heart failure to general medical wards and intensive care units in a tertiary care hospital in South India (CHROME-HF)

Kevin John John, (2019) A study of the clinical characteristics, risk factors and mortality outcomes of patients admitted with acute decompensated heart failure to general medical wards and intensive care units in a tertiary care hospital in South India (CHROME-HF). Masters thesis, Christian Medical College, Vellore.

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Abstract

OBJECTIVES: The study was conducted to determine the incidence density of mortality, median survival time, predictors of mortality and the costs incurred by patients admitted with acute decompensated heart failure. METHODS: This study was a prospective observational cohort study of patients admitted with acute decompensated heart failure, diagnosed clinically using the Boston Criteria. The recruitment of participants took place between January 2014 and December 2017 and patients were followed by telephonic interview prospectively till June 2018. Continuous data were described using mean and standard deviation. Person time was calculated in months and the incidence density was calculated. Time to event data was performed by using Kaplan-Meier estimate and was used to calculate the survival time. Unadjusted and adjusted analyses were done using Cox-proportional hazard regression analyses to determine predictors of mortality. RESULTS: A total of 338 patients participated in the study. Fifty one percent were males; the mean age 58.8 years. Fifty nine percent had diabetes, 55.6% hypertension, 24.3% dyslipidemia and 39.6% previously diagnosed heart failure. The incidence density of mortality was 6.47 deaths per 100 person-months. The median duration of survival was 921 days. Cyanosis, previous stroke or transient ischemic attack, lactate > 2mmol/L, troponin T > 50pg/ml and class D heart failure independently predicted 6-month mortality; Seattle heart failure model did not. The mean total direct cost of admission was ₹1,18,690.94.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Heart failure, Acute Decompensated Heart Failure, Heart Failure with Preserved Ejection Fraction, Heart Failure with Reduced Ejection Fraction, Heart Failure with Mid-Range Ejection Fraction.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 25 Aug 2019 02:17
Last Modified: 25 Aug 2019 02:17
URI: http://repository-tnmgrmu.ac.in/id/eprint/11190

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