Role of Platelet Indices in Differentiating the Causes of Thrombocytopenia in a Tertiary Care Hospital

Keerthy Aberna, A (2019) Role of Platelet Indices in Differentiating the Causes of Thrombocytopenia in a Tertiary Care Hospital. Masters thesis, Madras Medical College, Chennai.

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Abstract

BACKGROUND: Thrombocytopenia is defined as platelet counts below 1,50,000 cells/cu.mm, but they do not reveal the underlying pathology which could be either hypoproductive or hyperdestructive etiology. This study attempts to find the usefulness of these platelet indices in initial evaluation of patients with thrombocytopenia by assessing their variation in different clinical scenarios. AIM OF THE STUDY: 1. To evaluate the variation in platelet indices in establishing clinical correlation in patients presenting with thrombocytopenia. 2. To study the relationship of platelet indices with respect to the underlying mechanism of thrombocytopenia. MATERIALS & METHODS: This is a prospective study conducted in Institute of Pathology for a period of 1.5 years on patients with thrombocytopenia. Blood samples from 250 thrombocytopenia patients are obtained in EDTA anticoagulated tube and platelet indices such as plateletcrit (PCT), platelet distribution width (PDW), mean platelet volume (MPV), platelet large cell ratio (P-LCR) and immature platelet fraction (IPF) were calculated and analysed. RESULTS: Of all the platelet indices analysed, platelet distribution width (PDW), mean platelet volume (MPV), platelet large cell ratio (P-LCR) and immature platelet fraction (IPF) were found to be useful in discriminating the cause for hypoproductive and hyperdestructive thrombocytopenia. CONCLUSION: It is concluded that the platelet indices such as mean platelet volume, platelet distribution width, plateletcrit, platelet large cell ratio and immature platelet fraction helps in discriminating the etiological cause for thrombocytopenia. Among the platelet indices, mean platelet volume (MPV) provides much more reliable results in distinguishing both groups. Immature platelet fraction (IPF) plays in important role in measuring the bone marrow thrombopoietic activity. Platelet indices helps in providing many information preventing unnecessary invasive procedures in the patients such as bone marrow transfusion and unnecessary platelet transfusion.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Platelet indices, thrombocytopenia, hypoproductive group, hyperdestructive group.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 24 Aug 2019 11:46
Last Modified: 24 Aug 2019 11:46
URI: http://repository-tnmgrmu.ac.in/id/eprint/11177

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