Subhojit, Samanta (2012) Formulation And Evaluation Of Floating Tablets Of Cefixime Trihydrate Using Chitosan. Masters thesis, R V S College of Pharmaceutical Sciences, Coimbatore, Tamilnadu, India.
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Abstract
The major challenge faced by healthcare professionals in this view is that of gradation of the available drug delivery systems. The ultimate goal of any drug delivery system is effective disease/disorder management, minimum side effects and greater patient compliance in the cost effective manner. The drug therapeutic indices could be maximized while indices of adverse reactions or side effects could be minimized by regulating the drug release in body in a welldefined controlled manner. This would eliminate the haphazard and uncontrolled blood plasma profiles of drugs usually associated with conventional dosage forms. From the above experimental results it can be concluded that, Formulated floating tablets gave satisfactory results for various post compressional parameters like hardness, friability, thickness, weight variation and content uniformity. Sodium bicarbonate has predominant effect on the buoyancy lag time, while Chitosan, has predominant effect on total floating time and drug release. Carbopol also shows significant effect on drug release. Sodium alginate and Xanthan gum has given extra adhesion property and helped to maintain the integrity of the tablet. Floating matrix tablet with good floating and a controlled release pattern. Swelling index has a significant effect on the drug release. The formulations F8 and F9 showed higher swelling index compared to others. In-vitro release rate studies showed that the maximum drug release was observed in F8 and F9 formulations up to 12 hrs. Formulations F9 found to be stable at 45 o C and 75% RH for a period of 21 days. FT-IR studies revealed that there was no interaction between Cefixime and the polymers used. From the study it is evident that a promising gas powered controlled release floating tablets of Cefixime can be developed to increase gastric residence time and thereby increasing its bioavailability. Further detailed investigations are required to establish efficacy of these formulations and fix the required dose.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Formulation; Evaluation; Floating Tablets; Cefixime Trihydrate; Chitosan |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 06 Jul 2017 05:51 |
| Last Modified: | 06 Jul 2017 05:51 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1117 |
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