Histopathological Analysis and Study of Expression of Prostate Specific Membrane Antigen (PSMA) in Thyroid Follicular Neoplasms

Syed Abdullah Mohamed Ameen, (2019) Histopathological Analysis and Study of Expression of Prostate Specific Membrane Antigen (PSMA) in Thyroid Follicular Neoplasms. Masters thesis, Madurai Medical College, Madurai.


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BACKGROUND: Thyroid cancer is one of common endocrine cancers. Thyroid follicular neoplasms includes Follicular Adenoma, Follicular carcinoma and Follicular variant of Papillary Carcinoma. Diagnosis of a solitary encapsulated nodule with histomorphologic pattern is problematic for pathologists. PSMA is tumour associated neovasculature marker in prostrate cancers and in some solid malignant tumours. This study was conducted to evaluate the expression of PSMA in neovasculature of thyroid follicular neoplasms by immunohistochemistry to determine its usefulness for distinguishing between adenoma and carcinoma. METHODS: The study was carried out in the Department of Pathology, Madurai Medical College, Madurai, during the period from May 2016 to August 2018 on 113 specimens of thyroid follicular neoplasms received in the department. After adequate fixation, representative bits were taken, processed and stained with Haematoxylin and Eosin. The cases were classified based on WHO classification, 2017. Selected cases of thyroid follicular neoplasms were subjected to immunohistochemical evaluation with PSMA. RESULTS: Thyroid follicular neoplasm showed an incidence of 7.4%. Thyroid follicular neoplasm showed a Female male ratio of 7:1. The instensity and extent of staininig was signnificantly higher in follicular carcinoma and follicular variant of papillaey carcinoma than follicular adenoma. Fischer exact test was used to calculate and the P values obtained for intensity and extent of PSMA staining was less than 0.05. CONCLUSION: Expression of PSMA in neovasculature can be used to distinguish benign and malignant follicular neoplasm by assessing the intensity and extent of staining of endothelial cells.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Prostate Specific Membrane Antigen (PSMA), thyroid follicular neoplasms, Histopathological Analysis.
Subjects: MEDICAL > Pathology
Depositing User: Subramani R
Date Deposited: 23 Aug 2019 15:53
Last Modified: 24 Aug 2019 09:00
URI: http://repository-tnmgrmu.ac.in/id/eprint/11168

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