Nikhil, S (2019) Effects of Radiation Dose and Volume to the Larynx in Intensity Modulated Radiation Therapy of non-laryngeal Head and Neck Malignancies. Masters thesis, Christian Medical College, Vellore.
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Abstract
OBJECTIVES: To assess the effects of radiation dose and volume parameters to the larynx by assessing the mucosal reactions with flexible laryngoscopy and its correlation with voice-related quality of life using V-RQOL questionnaire, in patients undergoing Intensity-modulated radiation therapy for non-laryngeal head and neck malignancies. METHODS: DVH dose and volume parameters including Dmax, Dmean, V5 to V73.5 were obtained. Patients underwent flexible laryngoscopy prior to, during and at the completion of radiation therapy, and laryngeal oedema was graded as per RTOG grading criteria. The V-RQOL questionnaire was administered at same time points, and QOL scores including total, socioemotional and physical subdomains were calculated. RESULTS: Among the total of 31 patients, two and six of them had grade 2 oedema midway during and at the end of radiation therapy respectively. Ten (32.3%), eight (25.8%) and ten (32.3%) patients had a V-RQOL total, socio-emotional and physical scores less than 75 at midway assessment respectively. But this increased to 17 (54.8%), 15 (49.4%) and to (83.9%) at the end of radiation therapy respectively. There was a significant correlation of V65 with laryngeal oedema; and V60, V65 and V70 with the total V-RQOL score at the end of RT, V5 to V70 with socioemotional V-RQOL and V65 with the physical domain of the V-RQOL score. OAR constraints for larynx in IMRT could be V60 < 1% for grade 2 laryngeal oedema, and V65 < 1% for V-RQOL to be less than 75 at the end of radiation therapy. CONCLUSION: OAR constraints for larynx in IMRT could be V60 < 1% for grade 2 laryngeal oedema, and V65 < 1% for V-RQOL to be less than 75 at the end of radiation therapy.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | IMRT, voice-related quality of life, laryngeal oedema, V-RQOL questionnaire. |
| Subjects: | MEDICAL > Radio Therapy |
| Depositing User: | Subramani R |
| Date Deposited: | 19 Aug 2019 02:16 |
| Last Modified: | 19 Aug 2019 02:16 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/11049 |
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