Udhaya Kumar, M (2012) Formulation and Characterization of Gelatin Loaded Rosuvastatin Nanoparticles by Two Step Desolvation Method. Masters thesis, Adhiparasakthi College of Pharmacy, Melmaruvathur.
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Abstract
Recently, several technical advancements have resulted in the development of new techniques for drug delivery. These techniques are capable of controlling the rate of drug delivery, sustaining the duration of therapeutic activity and or targeting the delivery of drug to a tissue. These are referred to as novel drug delivery systems. And they have revolutionized the method of medication, provides a number of therapeutic benefits. The in-vitro released of Rosuvastatin was evaluated in phosphate buffer saline (pH6.8) up to 16hrs. The formulation F1 was released the drug 93.38% up to16 hours. and chosen the best among the formulations were prepared. Zeta potential was determined for the formulation F1 and it was found to be +ve value of 1.57mv.The in-vitro drug released data was applied to various kinetic models like zero order kinetics, Higuchi plot, first order kinetics, and Peppas plot by predict the drug release kinetics mechanism. The formulation F1 was best fitted the zero order kinetics. In short term stability studies the formulation F1 was showed that there was no remarkable changes in the % drug loading efficiency. Based on the % drug loading efficiency, zeta potential, in-vitro drug release profile, in-vitro drug release kinetics and stability studies the formulation F1 was found to be best one among the formulations (F1 to F8) were prepared. These nanoparticles can be promising agents for rational drug delivery in lipidemic condition.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Formulation; Characterization; Gelatin; Rosuvastatin Nanoparticles; Two Step Desolvation Method |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Ravindran C |
| Date Deposited: | 06 Jul 2017 04:55 |
| Last Modified: | 22 Oct 2017 09:42 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1103 |
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