Comparison between Fentanyl and Dexmedetomidine for Awake Fiberoptic Intubation

Mahaminu, S (2019) Comparison between Fentanyl and Dexmedetomidine for Awake Fiberoptic Intubation. Masters thesis, Government Theni Medical College, Theni.


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BACKGROUND: Endotracheal Intubation using a Fiberoptic bronchoscope in the Awake State, if performed without proper sedation, can be an extremely unpleasant and discomforting experience for the patient. At present, various classes of drugs are used. This study aims to test the efficacy and efficiency of Dexmedetomidine and Fentanyl on various parameters for sedation during Awake Fiberoptic Intubation. METHODOLOGY: A total of 60 patients posted for elective surgery undergoing Awake Fiberoptic Intubation were included. A detailed history, physical examination and routine investigations were done for all the patients. IV line was secured with a 18G Cannula. All vital parameters (HR, NIBP, Respiratory Rate, O2 Saturation, and ECG) were being continuously monitored. Baseline heart rate and Mean Arterial pressure readings were taken. Patients were randomly allocated into two groups, i. Group A – Receiving Inj. Dexmedetomidine at a dose of 1ug/kg over 10 min. ii. Group B – Receiving Inj. Fentanyl at a dose of 2ug/kg over 10 min. RESULTS: In analysis, we have observed that both Group A and Group B has comparable demographic characteristics (Age, sex, weight). Further, Ramsay sedation score (P value 0.004 < 0.05), cough score (P value 0.001 < 0.005), post intubation score (P value 0.002 < 0.05) were significantly favourable in Group A than in Group B. Significantly less desaturation were observed in Group A than Group B. Hemodynamic parameters like Heart Rate and Mean Arterial pressure did not show significant variability between baseline and post intubation values in Group A when compared with that of Group B. CONCLUSION: In our study, we have shown that Inj. Dexmedetomidine (1ug/kg over 10 min) is more effective than Inj. Fentanyl (2ug/kg over 10 min) for Awake Fiberoptic Intubation in terms of better sedation, intubating conditions and tolerance to intubation.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Dexmedetomidine, Fentanyl, Awake Fiberoptic Intubation, Sedation.
Subjects: MEDICAL > Anaesthesiology
Depositing User: Subramani R
Date Deposited: 19 Aug 2019 01:06
Last Modified: 19 Aug 2019 01:06

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