Comparison of Propofol and Etomidate Induction on Hemodynamic Response to Endotracleal in Tubation

Jamuna, S (2019) Comparison of Propofol and Etomidate Induction on Hemodynamic Response to Endotracleal in Tubation. Masters thesis, ESIC Medical College & Postgraduate Institute of Medical Science and Research, Chennai.


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BACKGROUND: Rapid induction and hemodynamic stability with minimal side effects are the most important characteristics desired from an ideal induction agent. MATERIALS AND METHODS: 60 patients between age group of 20 to 50 years, weighing 40 to 80 kgs with ASA physical status I and II who were scheduled for elective surgery under general anaesthesia, were randomly divided into group A (inj propofol 2.5mg /kg) and group B (inj etomidate 0.3mg/kg). The hemodynamic response to endotracheal intubation were measured at inducation, intubation and post intubation at 1, 2, 3, 5, and 10 min. RESULTS: The study showed that, etomidate maintained systolic blood pressure, diastolic blood pressure, mean arterial pressure compared to propofol at variable intervals post intubation. p value is less than 0.05 which is statistically significant. In terms of heart rate there was not much significant difference during induction and intubation but etomidate maintained heart rate following intubation within the range. Pain on injection was more common with propofol. Incidence of myoclonus was noted in patients with etomidate. CONCLUSION: The above study concludes that etomidate was more stable than propofol in term of hemodynamic variables.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Hemodynamic response, Etomidate, Propofol, Stress response, Induction, Intubation.
Subjects: MEDICAL > Anaesthesiology
Depositing User: Subramani R
Date Deposited: 19 Aug 2019 01:06
Last Modified: 19 Aug 2019 01:06

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