Aadhirai, M (2019) A Comparative study on Salivary Tumor Necrosis Factor-Αlpha Levels in Non-Smokers and Smokers with Chronic Periodontitis Before and After Phase-I Periodontal Therapy. Masters thesis, Tamil Nadu Government Dental College and Hospital, Chennai.
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Abstract
BACKGROUND: Tumor Necrosis Factor-alpha (TNF-α) is one of the proinflammatory cytokines that has been considered to be involved in the pathogenesis of periodontal disease as mediators of tissue destruction and serves as a biomarker for disease progression. Increased level of TNF-α has been identified in oral fluids of smokers. Recent advances have enabled the use of saliva as diagnostic fluid to detect the levels of these biomarkers. AIM OF THE STUDY: The aim of the present study is to compare the level of TNF-α in saliva of nonsmokers and smokers with chronic periodontitis before and after phase-I therapy. MATERIALS AND METHOD: Level of salivary TNF-α was determined in nonsmokers with chronic periodontitis (control group, n=15) and smokers with chronic periodontitis (study group, n=15) and compared with clinical parameters like gingival bleeding index, plaque index, probing pocket depth and clinical attachment level before and after phase-I therapy. RESULTS: Smokers had increased level of Salivary TNF-α compared to non-smokers at baseline. Statistically significant (p=0.00) reduction in clinical parameters and Salivary TNF-α level were seen among both non-smokers and smokers 3 months after Phase-I therapy. However, non-smokers showed significantly greater reduction in clinical parameters and Salivary TNF-α level compared to smokers. CONCLUSION: The present observations suggest that smoking is associated with elevated level of salivary TNF-α level and non-smokers exhibit better response to Phase-I therapy which is evident through significant decrease in level of salivary TNF-α after phase-I therapy compared to smokers.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Smoking, TNF-α, Phase-I Therapy, Chronic Periodontitis. |
| Subjects: | DENTAL > Periodontology |
| Depositing User: | Subramani R |
| Date Deposited: | 15 Aug 2019 03:24 |
| Last Modified: | 15 Aug 2019 03:24 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10892 |
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