Aiswarya, S (2019) A Comparative Evaluation of Serum Hepcidin and Interleukin-6 Levels Before and After Phase I Periodontal Therapy in Patients with Chronic and Aggressive Periodontitis. Masters thesis, Tamil Nadu Government Dental College and Hospital, Chennai.
|
Text
240202019aiswarya.pdf Download (11MB) | Preview |
|
|
Text
240202019aiswarya_abstract.pdf Download (111kB) | Preview |
Abstract
BACKGROUND: Periodontitis causes persistent inflammation, connective tissue breakdown and alveolar bone destruction, mediated by various types of Pro-inflammatory mediators. One of such pro-inflammatory mediator is interleukin–6, which is a signalling protein/cytokine produced by several cells including macrophages, neutrophils, keratinocytes, and fibroblasts, in response to stimulus such as infection and trauma. Interleukin-6 and lipopolysaccharides from microorganisms stimulate the hepatic expression of an acute-phase protein called hepcidin, which inhibits duodenal absorption of iron. This in turn may lead to anaemia of chronic disease. In an anaemic state there is increased periodontal destruction because of relative decrease in oxygen perfusion into tissues. AIM OF THE STUDY: The aim of this study is to determine and compare the level of serum hepcidin and interleukin-6 before and after phase-I periodontal therapy in patients with chronic and aggressive periodontitis. MATERIALS AND METHOD: In the present study, 45 subjects were selected, of which 15 were categorized as Group I which consisted of healthy subjects, 15 were categorized as Group II which consisted of patients with chronic periodontitis and another 15 were categorized as Group III which consisted of patients with aggressive periodontitis. The clinical parameters assessed were plaque index, gingival bleeding index, pocket probing depth, clinical attachment level. The laboratory parameters assessed were serum IL-6 and hepcidin level. All the parameters were assessed at baseline in group I, at baseline and 3 months after phase I therapy in group II and III. RESULTS: The levels of serum Hepcidin and IL-6 were elevated in chronic and aggressive periodontitis patients when compared with healthy subjects at baseline. However, there was no statistically significant difference in baseline values of Hepcidin and IL-6 between chronic and aggressive periodontitis patients. Following Phase I therapy there was a statistically significant reduction from baseline values in PI, GBI, PPD, CAL and serum levels of Hepcidin, IL-6 in chronic and aggressive periodontitis patients. CONCLUSION: Within the limitations of this study, it could be concluded that increased serum IL-6 and hepcidin level is associated with both chronic and aggressive periodontitis patients which increases the risk for the development of anemia of chronic disease. However, there was no statistically significant difference in baseline values of Hepcidin and IL-6 between chronic and aggressive periodontitis patients. Following phase I therapy the levels of both IL-6 and Hepcidin reduced in chronic and aggressive periodontitis patients. In future, studies with a larger sample size may be employed to further establish the association between serum Hepcidin levels and periodontal status of the patient and to evaluate the efficiency of phase I therapy in reducing serum IL-6 and Hepcidin levels. This will help to reduce the systemic burden of the patient like development of anaemia, CVS complications etc.,
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Hepcidin, Interleukin-6, Anaemia of chronic disease, chronic periodontitis, Aggressive periodontitis. |
| Subjects: | DENTAL > Periodontology |
| Depositing User: | Subramani R |
| Date Deposited: | 15 Aug 2019 03:22 |
| Last Modified: | 15 Aug 2019 03:22 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10891 |
Actions (login required)
 |
View Item |
