A Comparative Evaluation of Serum Leptin Level Before and After Phase I Periodontal Therapy in Chronic Periodontitis

Balamurugan, M (2019) A Comparative Evaluation of Serum Leptin Level Before and After Phase I Periodontal Therapy in Chronic Periodontitis. Masters thesis, Tamil Nadu Government Dental College and Hospital, Chennai.


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BACKGROUND: Leptin is an adipose tissue derived pleiotrophic hormone that plays an important role in the inflammatory diseases of the human being including the inflammatory periodontal disease. The role of non-surgical periodontal therapy (NSPT) in altering the leptin concentrations in serum of CP patients is yet to be ascertained. AIM OF THE STUDY: The aim of the present study is to assess and evaluate the concentration of leptin in serum before and after phase I periodontal therapy in chronic periodontitis patients. MATERIALS AND METHOD: Level of serum leptin was determined in healthy subjects (control group, n=25) and patients with chronic periodontitis (study group, n=25) and compared with clinical parameters like gingival bleeding index, plaque index, probing pocket depth and clinical attachment level before and after phase-I therapy. RESULTS: Clinical parameters and leptin level were increased in the serum of patients with chronic periodontitis before phase I therapy compared to healthy subjects. Statistically significant (p=0.00) reduction in clinical parameters and serum leptin level were seen after Phase-I therapy. CONCLUSION: These results suggest that periodontal inflammation may up-regulate serum leptin level and increase clinical parameter values in patients with chronic periodontitis and phase I therapy was able to restore the serum leptin levels and clinical parameters.

Item Type: Thesis (Masters)
Uncontrolled Keywords: Serum Leptin, Chronic periodontitis, Phase I therapy .
Subjects: DENTAL > Periodontology
Depositing User: Subramani R
Date Deposited: 15 Aug 2019 03:19
Last Modified: 15 Aug 2019 03:19
URI: http://repository-tnmgrmu.ac.in/id/eprint/10889

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