Priyanka Elizabeth, Kurian (2018) Clinical Study on the Usefulness of Tiotropium in Poorly Controlled Asthma Patients. Masters thesis, KMCH College of Pharmacy, Coimbatore.
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Abstract
BACKGROUND: Asthma is the chronic disorder of airways in which many cells and cellular components are involved. Asthma requiring treatment with high-dose IC, plus a second controller and/or SC to prevent it from becoming uncontrolled or that remains uncontrolled despite this therapy is termed as Severe uncontrolled asthma. The prime objective of the study was to assess the usefulness of Tiotropium in poorly controlled asthma patients. METHODS: It is a retrospective and prospective observational study which was conducted in Kovai Medical Center and Hospital. A total of 70 patients with poorly controlled asthma were enrolled in this study. The assessment of asthma severity and control over the disease was measured by using Asthma Control Questionnaire (ACQ). The quality of life of the patients were assessed by using Mini Asthma Quality of Life Questionnaire (MiniAQLQ). Data were analysed by using descriptive and inferential statistics. RESULTS: Among the 70 patients 47 were males and 23 were females. Majority of the patients were in the age group above 40, mostly in 61-70 age group. Most of patients had poor control or exacerbation of asthma due to exposure towards the occupational allergens. 55 patients had exposure towards allergens as part of their occupation and lead to poor control over asthma. The prevalence of comorbid conditions was also analysed and it was found that 31 patients were GERD diagnosed and 21 were not diagnosed as GERD patients but they were symptomatic and had frequent heart burn sensation. Tiotropium was given as step-up therapy along with ICS. CONCLUSION: In this study, patients showed significant improvement in the asthma control and quality of life, which was measured using ACQ and MiniAQLQ respectively. The FEV1 value showed significant improvement within 3 month treatment. On statistical analysis significant changes were observed for before and after the initiation of Tiotropium. No serious adverse effects were reported, only a small number of patients reported adverse effects (dry mouth). Thus from the study it was concluded that Tiotropium as step-up therapy along with ICS had beneficial effect on poorly controlled asthma patients.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg. No: 261640604 |
| Uncontrolled Keywords: | Tiotropium ; Poorly Controlled Asthma Patients ; Clinical study. |
| Subjects: | PHARMACY > Pharmacy Practice |
| Depositing User: | Subramani R |
| Date Deposited: | 02 Jul 2019 15:51 |
| Last Modified: | 08 Jul 2019 03:04 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10708 |
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