Binil Baby, (2018) A Prospective, Observational Study on Prevalence of Cardiovascular Risk Factors and Statin use in Patients with Epilepsy and Assessment of Quality of Life. Masters thesis, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore.
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Abstract
The work entitled "A prospective, observational study on prevalence of cardiovascular risk factors and statin use in patients with epilepsy and assessment of quality of life” was conducted in the department of neurology of a 1000 bedded multispecialty hospital. The study protocol was prepared and submitted to the ethical committee of the hospital and official approval was obtained to carry out the study after ensuring the scope of the study in the department of neurology of the study hospital. After receiving the official approval, the study was conducted for a period for a period of nine months from December 2017 to August 2018. A total of 130 cases with epilepsy were collected. Prior consents from the patients were taken after explaining them the need of the study. The analysis of the study conducted for eight months revealed that there were 79 (61%) male patients and 51 (39%) female patients who fit into the inclusion criteria. The age categorization of the study population indicated that maximum number of patients are between the age group of 51-65 (36%) followed by age group of 35-50 (32%). Hypertension (28%) and Diabetes (18%) were the major comorbid conditions among epilepsy patients. Patients with smoking (11%) and drinking (7%) habits were also documented during the study. No patients with previous coronary artery disease were included in the study. The majority of the patients were known cases of epilepsy for more than a year (83%). The majority of the patients were diagnosed with generalised tonic clonic seizures (37.5%), followed by partial seizures with secondary generalisation (31%). To find out any rationality in therapy, an attempt was made to know about the concurrent drugs prescribed. The results revealed that proton pump inhibitors (89%), antibiotics (51%), lipid lowering agents (52%) and antiemetics (58%) were the major category of drugs prescribed. Antidiabetic drugs (16%) and antihypertensive drugs (26%) dr were major category of drugs prescribed since high prevalence of hypertension and diabetes was observed as comorbidity in the study population. Levetiracetam (84%), was the maximum prescribed antiepileptic drug in the study department, followed by fosphenytoin (32%), lacosamide (24%) and clobazam (20%). The drug interaction between atorvastatin and pantoprazole was the mostly recorded drug interaction, which was observed in 15 patients with moderate severity. Among the study population 85 (65%) patients were receiving polypharmacy and 45 (35%) patients were receiving monotherapy. A total of 68 (52%) of patients were receiving lipid lowering drugs, in which 51 (39%) patients were having lipid profile data. The health related quality of life of epilepsy patients were assessed by direct interviewing the patients with QOLIE-10-P questionnaire. The QOLIE-I0-P questionnaire provided individual patients with an opportunity to denote epilepsy-related problems and express their concerns to health-care providers. The brevity of this screening tool has the potential of saving time without sacrificing the quality of information collected or interfering with the relationship between the patient and the researcher. The QOLIE- 10-P questionnaire is a simple screening questionnaire that can be completed easily and quickly by patients. The 10 items fall into three distinct topics as (a) medication effects, (b) mental health, and (c) role functioning and seizure worry, all of which pertain to aspects of daily living for persons with epilepsy. The 11th question enables the patient to express his feelings on the burden of epilepsy on his/her normal life. The scoring tool for QOLIE-10-P questionnaire was obtained from the QOLIE development group and used. The mean score of the first 10 questions were calculated and its mean was multiplied with the score obtained for the 11th question to produce the weighted final score.
| Item Type: | Thesis (Masters) |
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| Additional Information: | REG.No. 261640103 |
| Uncontrolled Keywords: | Prevalence ; Cardiovascular Risk Factors ; Statin ; Epilepsy ; Quality of Life ; Prospective, Observational Study. |
| Subjects: | PHARMACY > Pharmacy Practice |
| Depositing User: | Subramani R |
| Date Deposited: | 02 Jul 2019 14:48 |
| Last Modified: | 03 Jul 2019 01:21 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10682 |
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