Elamaran, C (2011) High Sensitive C-Reactive Protein (hs-CRP) and its Correlation with Clinical profile and Angiographic Severity of Coronary Artery Disease. Masters thesis, Stanley Medical College, Chennai.
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Abstract
INTRODUCTION : The importance of risk factors such as diabetes mellitus (DM), hypertension, smoking, family history of premature heart disease, dyslipidaemia, male gender and advanced age has been established in predicting the risk of cardiovascular disease (CVD) by numerous studies. However, in half of those who develop CVD, the established risk factors are largely absent. Identification of additional factors is therefore necessary to identify more effectively those at risk of CVD. Over the past decade, identification of novel risk factors and predictors for CVD has been an area of major interest in preventive cardiology. Serum high sensitivity C-reactive protein hs-CRP, a biomarker of inflammation, has been shown to effectively predict the risk of adverse cardiovascular (CV) events consistently. Despite its initial role as a marker of vascular inflammation, recent research has established the role of CRP in atherogenesis. It is involved throughout the evolvement of atheromatous lesions and is detectable even in the initial phases of plaque development. AIM OF THE STUDY : 1. To correlate the levels of hs-C reactive protein with angiographic severity of coronary artery stenosis in patients with IHD admitted for CAG in Stanley Medical College. 2. To correlate the levels of hs-C reactive protein with vessel score. 3. To correlate the levels of hs C reactive protein with stenosis score. CONCLUSION : CRP levels were elevated in our study group irrespective of other traditional risk factors in Acute coronary syndromes. Gensini scoring of CAD angiographic severity is in linear correlation to mean CRP levels. CRP Levels is correlating well with angiographic stenosis severity. Low CRP (<1 mg) is associated with less severe stenotic lesions. High CRP (>3 mg )is associated with severe stenotic lesions. Number of vessels involved in CAD patients correlates directly with CRP level groupings. Higher the CRP levels, more vessels involved. Those with Low CRP (<1 mg), had single vessel disease. Those with left main disease and its equivalents, triple vessel disease had very high mean CRP levels. It appears that ejection fraction did not predict CRP elevation.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | High Sensitive C-Reactive Protein ; hs-CRP ; Angiographic Severity ; Coronary Artery Disease ; Clinical profile. |
| Subjects: | MEDICAL > Cardiology |
| Depositing User: | Kambaraman B |
| Date Deposited: | 06 Jul 2017 02:37 |
| Last Modified: | 06 Jul 2017 10:11 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1067 |
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