Muhammed Rashid, V P (2018) Evaluation of Anti Diabetic Activity of Ethanolic Root Extract of Premna Corymbosa Rottl against Streptozotocin and Nicotinamide in Diabetic Rats. Masters thesis, Nandha College of Pharmacy, Erode.
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Abstract
A large shrub or a small tree up to 9cm in height with yellowish lenticellate bark, spinous large branches and yellowish brown woody aromatic root; leaves simple, opposite, sometimes whorled, elliptic-ovate, membranous when young, coriaceous when mature, entire or irregularly toothed, primary lateral nerves 4-6 pairs; flowers small, greenish yellow or greenish white with a strong disagreeable odour in corymbiform cymose panicles; fruits globose drupes, black when ripe with the persistent saucer-shaped calyx surrounding its base. PLAN OF WORK: The following in-vitro and in-vivo biochemical markers studies and histopathology of tissue were done with of ethanolic root extract of Premna corymbosa Rottl. 1. Collection of plant materials. 2. Authentication of plant materials. 3. Extraction of plant material using Soxhlet apparatus. 4. Determination of phytochemical constituents present in the extract. 5. Pharmacological activities. 6. Anti-diabetic screening models: Streptozotocin - Nicotinamide induced diabetes in experimental animals. 7. Parameters observed and biochemical evaluation: Blood Glucose Level, Liver function tests, Renal function tests, Lipid Profile. CONCLUSION: Several factors underlie the growing popularity of herbal treatments for a variety of chronic conditions. Interestingly, people who utilize alternative therapies are not necessarily uniformed. Many people using herbal medicines find the health care alternatives are more congruent with their own values, beliefs and philosophical orientation towards health and life. The root of Premna corymbosa was selected for the evaluation of antidiabetic potential in STZ-nicotinamide induced diabetic rat model.The root extract was extracted by hot percolation using ethanol as a solvent in soxhlet apparatus and the preliminary phytochemical screening was performed and it shows that the ethanolic root extract of Premna corymbosa contains alkaloids, glycosides, flavonoids and tannins. Safety profile is essential for the drugs obtained from the plant origin. The level of toxicity can be evaluated by toxicological studies.From the results it was concluded that the ethanolic root extract of Premna corymbosa showed significant anti diabetic activity in a dose dependant manner compared to the standard drug glibenclamide. The result also showed significantdecrease in the liver Alkaline phosphatase(ALP), Aspartate amino transferase(AST), Alanine amino transferase(ALT), serum urea level, cholesterol, triglycerides, VLDL and LDL was in STZ-nicotinamide induced diabetic animals when compared to control group. It is concluded that ethanolic root extract of Premna corymbosa showed significant effect in STZ-nicotinamide induced diabetic rats. Further studies are necessary to examine the underlying mechanism of hypoglycemic effect and to isolate the active compound(s) responsible for antidiabetic activities.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.261625403 |
| Uncontrolled Keywords: | Anti Diabetic Activity ; Ethanolic Root Extract ; Premna Corymbosa Rottl ; Streptozotocin ; Nicotinamide ; Diabetic Rats. |
| Subjects: | PHARMACY > Pharmacology |
| Depositing User: | Subramani R |
| Date Deposited: | 30 Jun 2019 11:18 |
| Last Modified: | 30 Jun 2019 11:18 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10664 |
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