Jimmy, Alex (2018) Characterization of Physalis Lagascae for its In Vitro Anti-Cancer Activity. Masters thesis, Annai JKK Sampoorani Ammal College of Pharmacy, Komarapalayam.
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Abstract
The result of the shows the presence of compounds like carbohydrates, alkaloids, saponins, tannins, phytosterols and steroids and flavonoids. The MTT assay and the Chromatographic studies give more information about the drug. When we go through the MTT assay it showed that the ethanolic extract of Physalis lagascae showed the in vitro anti-cancer activity but it’s very less when we compare it to the standard drug like the etoposide. The cell with standard drug etoposide showed 28% and the cell with sample showed 59.6%.The results can be analyzed as the cell with sample showed value higher than the cell with standard drug produced. The MTT assay gives clear idea about the in vitro anticancer activity of the plant extract. The chromatographic study showed that the presence of the compound Quercetine which belongs to the group of flavonoids in the ethanolic extract of the plant Physalis lagascae. The chromatographic study showed that the standard reference marker Quercetine just moved from the initial point and the garlic acid extract didn’t show any movement from the initial point. This said that the sample contain Quercetine which belongs to the flavonoid group. The importance of flavonoid is it has the property of anti-oxidant, which is very helpful in the mechanism of anti-cancer activity.so, we can say that the extract of plant Physalis lagascae shows the anti-cancer activity. When we analyze both the result the MTT assay shows the plant extract of Physalis lagascaehas anti-cancer action .and the chromatographic study shows that the extract contain Quercetine which belongs to the group of flavonoids which having the property of anti-oxidant action which support the anti-cancer action of the plant.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.261615602 |
| Uncontrolled Keywords: | Physalis Lagascae ; Characterization ; In Vitro Anti-Cancer Activity. |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Subramani R |
| Date Deposited: | 28 Jun 2019 02:35 |
| Last Modified: | 28 Jun 2019 02:35 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10636 |
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