Synthesis and In-Vitro Anticancer Evaluation of Novel 5-Substituted Thiazolidinediones

Sekar, B (2018) Synthesis and In-Vitro Anticancer Evaluation of Novel 5-Substituted Thiazolidinediones. Masters thesis, J.K.K.Nattraja College of Pharmacy, Komarapalayam.


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In summary, a new series of 4-substituted benzylidene thiazolidinedione derivatives were synthesized. These title compounds containing seven different substituent’s at C-5 were screened for their invitro anti-cancer activity. Most of the test compounds were found to exhibit significant anti-cancer activity. Among the substituent’s at C-5, 4-dimethylaminocinnamoyl phenyl substituent showed maximum potency, while 2-hydroxy phenyl substituent showed equipotent activity but the4-dimethylamino) phenyl,4-methoxyphenyl and but-2-enylidenesubstituent’s exhibited least activity when compare to other substituent’s. The order of activity at C-5 is4-dimethylaminocinnamoyl phenyl ≥2-hydroxy phenyl ≥4-dimethylamino) phenyl ≥4-methoxyphenyl ≥ but-2-enylidene group. Among the test compounds, compound 5-(4-chlorobenzylidene)thiazolidine-2,4-dione (TZD7) was found to be the most active agent which showed 74.85 percentage of cell inhibition against the human cervical cancer cell line (HeLa) in the highest concentration, which have p-chloro group at the 5th position in the thiazolidinedione nucleus. Hence this molecule can be selected as a lead molecule of the present study for further exploitation.

Item Type: Thesis (Masters)
Additional Information: REG.No.261615207
Uncontrolled Keywords: Novel 5-Substituted Thiazolidinediones ; Synthesis ; In-Vitro Anticancer Evaluation.
Subjects: PHARMACY > Pharmaceutical Chemistry
Depositing User: Subramani R
Date Deposited: 28 Jun 2019 01:56
Last Modified: 28 Jun 2019 01:56

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