Sweetha, S Rani (2018) Novel 4-Thiazolidinone Derivatives as α- Amylase Inhibitory Activity: Synthesis, Characterization and Biological Evaluation. Masters thesis, J.K.K.Nattraja College of Pharmacy, Komarapalayam.
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Abstract
In summary, a new series of 2-(4-substituted phenyl)-3-(4, 6-dimethylpyrimidin-2-yl) thiazolidin-4-one (T1-T5) were synthesized. These title compounds containing five different substituent’s at C-4 position were screened for their α-amylase inhibitory activity. Most of the test compounds were found to exhibit significant α-amylase inhibitory activity in the lowest concentration. Among the substituent’s at C-4, p-chlorophenyl substituent shows maximum α-amylase enzyme inhibitory potency, while 4- aminophenyl and 4-dimethylaminophenyl substituent showed equipotent or has little less α-amylase inhibitory activity when compared to compound T1, but the dimethylamino cinnamldehyde and 4-hydroxy phenyl substituent exhibited least α-amylase inhibitory activity when compare to other substituents. The order of activity at C-4 is p-chloro phenyl ≥ p-amino phenyl ≥ p-dimethylaminophenyl ≥ 4- hydroxyl phenyl ≥ pdimethylamino cinnamldehyde substituents. Among the test compounds, compound 2-(4-chlorophenyl)-3-(4, 6-dimethylpyrimidin-2-yl)thiazolidin-4-one (T1) was found to be the most active agent which showed 88.00 μg/ml α-amylase inhibition in the highest concentration, which have p-chloro group in the thiazolidinone nucleus. Hence this molecule can be selected as a lead molecule of the present study for further exploitation.
| Item Type: | Thesis (Masters) |
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| Additional Information: | REG.NO. 261615208 |
| Uncontrolled Keywords: | Novel 4-Thiazolidinone Derivatives ; α- Amylase Inhibitory Activity ; Synthesis ; Characterization ; Biological Evaluation. |
| Subjects: | PHARMACY > Pharmaceutical Chemistry |
| Depositing User: | Subramani R |
| Date Deposited: | 28 Jun 2019 01:37 |
| Last Modified: | 28 Jun 2019 01:37 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10628 |
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