Swathi, P (2013) Dissolution Enhancement of Aceclofenac Solid Dispersion Prepared with Hydrophilic Carriers by Solvent Evaporation Method. Masters thesis, Swamy Vivekanandha College of Pharmacy, Tiruchengode.
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Abstract
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) having antiinflammatory and analgesic properties, and is widely used in the treatment of rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. One of the major problems with this drug is its low solubility in biological fluids, which results into poor bioavailability after oral administration. Therefore, solid dispersions (SDs) of aceclofenac were prepared using PEG6000, PVP and HPMC to increase its aqueous solubility. Aceclofenac SDs was prepared in 1:1, 1:2 and 1:1:1 ratios of the drug to polymer (by weight). In-vitro release profiles of all SDs (F-1 to F-9) were comparatively evaluated and also studied against pure aceclofenac. Faster dissolution was exhibited by solid dispersion containing (1:1:1) ratio of drug: PEG6000: PVP. The increase in dissolution rate of the drug may be due to increase in wettability, hydrophilic nature of the carrier and due to reduction in drug crystallinity. The prepared solid dispersion was subjected for percentage practical yield, drug content, infrared (IR) spectroscopic and differential scanning calorimetry (DSC) studies. Absence of significant drug-carrier interaction was confirmed by infrared spectroscopic (IR) and differential scanning calorimetry (DSC) data. Solid dispersion of formulation (F7) aceclofenac, PEG 6000 and PVP combination prepared in (1:1:1) ratio showed excellent solubility and the dissolution rate was found to be 96.21% was selected as the best formulation in this study.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg. No: 26115404 |
| Uncontrolled Keywords: | Dissolution Enhancement ; Aceclofenac Solid Dispersion ; Hydrophilic Carriers ; Solvent Evaporation Method. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Subramani R |
| Date Deposited: | 28 Jun 2019 01:08 |
| Last Modified: | 28 Jun 2019 01:08 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10624 |
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