Mohamed Eltayeb Hassan Homaida, (2014) Formulation and Gastric Floating Drug Delivery Systems of Cefadroxil Matrix Sustained Release Tablet. Masters thesis, Annai Veilankanni’s Pharmacy College, Chennai.
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Abstract
In present work, attempts have been made to formulate floating matrix extended release tablets of cefadroxil, by using different ratio of hydrophilic polymer HPMC K100M and sodium carboxy methyl cellulose and sodium bicarbonate as a gas generating agent. Cefadroxil is a acid stable broad-spectrum antibiotic of the cephalosporin type, effective in Gram-positive and Gram-negative bacterial infections. It is a bactericidal antibiotic. The floating Matrix tablets were prepared by wet granulation technique. Cefadroxil meets all the ideal characteristics to formulate in the form of extended release drug delivery system. Under preformulation study, the organoleptic properties were complied with the IP specification. Physical properties such as bulk density and tapped density were more in case of granules ready for compression than that on cefadroxil raw powder. melting point determination were given the information about the purity of the drug powder respectively. The result of angle of repose of drug powder showed the poor flow properties. Solution properties i.e pH of the solution and solubility were evaluated, results were complied with the pharmacopoeial specification. All the formulations were evaluated on the basis of pharmacopoeial specifications. Shape of the tablets was round standard concave hardness, weight variation, floating time study, dissolution test were carried out. Assay of cefadroxil was carried out by both uv spectrophotometric method and hplc method. Assay (UV METHOD) was carried out for F5 and F10 was found to be 98.02% and 97.84%. Assay (HPLC METHOD) was carried out for F5 mg) and F10 was found to be 97.76% and 97.46%. Infra Red spectrum of cefadoxil matches with the standard spectrum as well in tablet there are no any additional peak formation. Stability studies of the selected formulated tablets were carried out by keeping the tablets at room temperature and at 40 oC + 2 oC/ 75 + 5 % RH (stability chamber) for 30 days. All the parameters were within the limit after 30 days. The mechanism of drug release form matrix tablets were combination of swelling diffusion and erosion in all cases. The release rate of cefadroxil matrix floating tablets followed near mixed order kinetics, which was obtained by plotting, a graph of cumulative percentage drug release Vs time. CONCLUSION: In the present study attempts were made to formulate two different strength (125mg & 250 mg) of cefadroxil floating matrix extended release tablet, by wet granulation. The In Vitro study, shows formulation No.5 & 10 were well suited to be extended release formulation due to floating up to 24 hrs. Formulation F5 & F10 was found 0074o obey nearly zero to zero order drug release governed by diffusion through swollen matrix, showing anlomous diffusion or non fickian transport. Infrared spectrum of tablet reveals that there is no interaction of the polymer and tablet matrix with cefadroxil. Stability study is passed as per specification. Further in-vivo and continuation of stability study are recommended.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg No: 261211054 |
| Uncontrolled Keywords: | Cefadroxil Matrix Sustained Release Tablet ; Formulation ; Gastric Floating Drug Delivery Systems. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Subramani R |
| Date Deposited: | 27 Jun 2019 02:05 |
| Last Modified: | 27 Jun 2019 04:23 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10621 |
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