Ushadevi, C (2018) Formulation and Evaluation of Floating Microparticles of Amlodipine Besylate. Masters thesis, Cherraan's College of Pharmacy, Coimbatore.
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Abstract
Floating amlodipine besylate microparticles using polymer ethylcellulose, HPMC, Poly vinyl pyrrolidine and Eudragit RS 100 was developed by solvent evaporation method and it was found to be a suitable floating oral drug delivery system in terms of particle size distribution, drug loading capacity and Sustained release amlodipine besylate microparticles obtained was spherical in shape, discrete and free flow in nature. It can be concluded that, • Polymer-drug ratio influence the particle size as well as drug release pattern of microsphere. • Entrapment efficiency of drug loaded batches F1 to F9 were determined and it was found that F2 and F9 had a better drug entrapment efficiency of 95% and 96%. • Drug loading efficiency was better with F9 showed 96%. • Percentage yield from all the formulation were high and F9 showed good percentage yield of 96%. • Flow properties were determined for all the formulations F1 to F9. The result of Carr’s index and angle of repose values indicated that all the formulations showed good flow properties. • In-vitro drug release from all the formulations was found to be slow and sustained over the period of 8 hours was found to be 96.89%. • Stability studies of formulated Amlodipine microparticles was done at 40° C± 2°C and 75%±5 RH. Evaluating initial month and after one month founded that there is no significant changes in appearance, solubility, colour, particle size, swelling index, in-vitro drug release. • Decided to do in-vivo studies in future.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg. No.261611004 |
| Uncontrolled Keywords: | Floating Microparticles ; Amlodipine Besylate ; Formulation ; Evaluation. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Subramani R |
| Date Deposited: | 27 Jun 2019 01:49 |
| Last Modified: | 27 Jun 2019 01:49 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10619 |
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