Shobana, M (2018) Formulation and Evaluation of Fast Dissolving Oral Film of Sitagliptin Phosphate by Solvent Casting Method. Masters thesis, Cherraan's College of Pharmacy, Coimbatore.
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Abstract
The primary objective of this work was to develop a mouth dissolving film with Sitagliptin phosphate, along with basic ingredients like polymers, plasticizers, sweetener, saliva stimulating agent and flavor. The films were prepared by solvent casting method. HPMC E50 cps, which was not able to impart thickness to the film. HPMC E15 shown good flexibility. The plasticizer propylene glycol which was not able to impart flexibility and folding endurance to the film. PEG 400 produced good folding endurance, tensile strength and percent elongation. The optimized formulation (F3) was shown good mouth feel, folding endurance, instant drug release as well as good mechanical properties. The F3, shown less disintegration time of 20 seconds and 99% drug released within 3 minutes while the marketed formulation took 1 hour. Therefore rapid drug release was achieved for immediate onset of action which is beneficial when compared to conventional tablet dosage form.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No. 261611002 |
| Uncontrolled Keywords: | Fast Dissolving Oral Film ; Sitagliptin Phosphate ; Solvent Casting Method ; Formulation ; Evaluation. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Subramani R |
| Date Deposited: | 27 Jun 2019 01:38 |
| Last Modified: | 27 Jun 2019 01:38 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10618 |
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