Shyamla, S (2017) Development and In Vitro - In Vivo Evaluation of Gastroretentive Drug Delivery of Nizatidine Using Natural and Semi Synthetic Polymers. Masters thesis, KMCH College of Pharmacy, Coimbatore.
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Abstract
Drug delivery through the numerous gastroretentive approaches has opened a new horizon for effective way of increasing patient compliance and increasing bioavailability of variety of drugs through oral rout. Many approaches with use of different polymers and other constituents can produce different range of gastroretentive systems. Especially the floating drug delivery system is the most widely used in gastroretentive dosage forms. However a lot of work is still needed to be done to overcome the different physiological and pharmaceutical barriers to develop the more effective gastroretentive dosage forms. 2. Nizatidine floating tablets were successfully prepared with hydrophilic polymers like HPMC K4M and Tamarind seed polysaccharide. 3. All formulations were evaluated for Compressibility Index, Angle of repose and Hausner ratio. The results indicated that the final blend had good flow and suited for direct compression technique. 4. From the pre-formulation studies for drug excipient compatibility it was observed that Nizatidine, doesn’t show any physical or chemical incompatibility between the drug and other excipients. 5. All formulations were tested for post compression parameters like hardness, thickness, weight variation, friability and drug content. All estimated parameters were found to be within the limits. This indicated that all the prepared formulations were good. 6. All formulations were tested for buoyancy properties like floating lag time & total floating time. Almost all the formulations showed satisfactory results. 7. All formulations were tested for in vitro drug release. The optimized formulations among HPMC K4M and Tamarind seed polysaccharide are F8. It contains combination of polymer with tamarind seed polysaccharide and HPMC K4M (1:1)ratio which exhibit least floating lag time in 50 sec and with maximum rate of drug release of 98.28% So, this formulation was considered to be the optimized formulation. 8. Comparitively kinetic model obtained for the floating tablet of nizatidine best formulation F8 and for other formulation are r2 in Zero order kinetics and mechanism is fit to Kormeyer –Peppa’s model. 9. The F8 formulation was chosen as the best formulation among all the other formulations. So stability studies are performed after one month also the formulation is stable. 10. Use of Tamarind seed polysaccharides enhanced the floating lag time, maintained the Controlled release of drugs. CONCLUSION: It can be concluded that the combination of tamarind seed polysaccharide and HPMC in ratio of (1:1) can be used to develop controlled release floating tablets of Nizatidine by incorporating sodium bicarbonate and citric acid for gas generation. However, clinical experiment on the human should be concluded with optimized formulation F8 in order to correlate in vivo performance with its in vitro behaviour.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg. No. 261610901 |
| Uncontrolled Keywords: | Gastroretentive Drug Delivery ; Nizatidine ; Natural and Semi Synthetic Polymers ; Development ; In Vitro ; In Vivo Evaluation. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Subramani R |
| Date Deposited: | 27 Jun 2019 01:29 |
| Last Modified: | 27 Jun 2019 04:18 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10616 |
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