Meeranmydeen, I (2018) Formulation and Evaluation of Enteric Coated Tablets of Duloxetine Hydrochloride. Masters thesis, Sankaralingam Bhuvanesvari College of Pharmacy, Sivakasi.
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Abstract
A total of five formulations (F-I to F-V) of Duloxetine hydrochloride tablets were developed by direct compression method. The work was carried out to delay the release of Duloxetine hydrochloride by using enteric polymer. From all the above observation it was concluded that the formulation F-V containing calcium carbonate as an alkalizing agent along with mannitol and microcrystalline cellulose as diluent was selected as the best formulation among the five formulations and 8% coating solution of Protectab enteric M1 polymer was applied as enteric coating. Formulation F-V showed better drug resistance in acidic medium and release the drug in alkaline medium as per I.P specification and showed rapid drug release in intestine than marketed Duloxetine hydrochloride enteric coated tablet. Hence the study concluded that formulation F-V satisfied all the criteria for enteric coating tablets.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg. No. 261610353 |
| Uncontrolled Keywords: | Duloxetine Hydrochloride ; Enteric Coated Tablets ; Formulation ; Evaluation. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Subramani R |
| Date Deposited: | 25 Jun 2019 03:35 |
| Last Modified: | 25 Jun 2019 03:35 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10609 |
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