Raghu, J (2018) Formulation and Evaluation of Levofloxacin Hemihydrate Mucoadhesive Microspheres for Eradication of Helicobacter Pylori Infection. Masters thesis, J.K.K.Nattraja College of Pharmacy, Komarapalayam.
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Abstract
The aim of the present research work was to formulate and evaluate mucoadhesive microspheres of levofloxacin hemihydrate using the mucoadhesive polymers (carbopol 974P and HPMC K4M for H. pylori eradication. These two polymers (carbopol 974P and HPMC K4M) act as complimentary to each other in that carbopol 974P increases the mucoadhesion and HPMC K4M other hand helps to control drug release. From all of the experiments performed, it can be concluded that the developed mucoadhesive polymers can be successful in the effective for treatment of H. pylori infection. The developed mucoadhesive polymers may decrease the short comings of conventional drug delivery systems. It can also deliver the antimicrobial effect to the infected mucosal area. It is possible that mucoadhesive polymers with uniform gastric distribution can targetthe H. pylori-infected sites more effectively and could optimize antibiotic monotherapy of H. pylori, which could be of definite therapeutic benefit. Further more, inorder to confirm the efficiency of developed formulations, In-vivo buoyancy and pharmacokinetic studies are necessary.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg. No: 261610255 |
| Uncontrolled Keywords: | Levofloxacin Hemihydrate Mucoadhesive Microspheres ; Eradication ; Helicobacter Pylori Infection ; Formulation ; Evaluation. |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Subramani R |
| Date Deposited: | 25 Jun 2019 02:06 |
| Last Modified: | 25 Jun 2019 02:06 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10603 |
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