Santhosh Kumar, R (2013) Formulation and Evaluation of Serratiopeptidase tablets. Masters thesis, PGP College of Pharmaceutical Science and Research Institute, Namakkal.
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Abstract
Serratiopeptidase is derived from bacteria belonging to genus Serratia. Serratiopeptidase tablets used in the treatment of viral diseases and hepatitis. In this study Serratiopeptidase enteric coated tablets were prepared by using HPMC phthalate, HPMC 15cps (Polymer). Several formulations were made with varying the concentrations of drug polymer and enteric coating tablets were done by wet granulation method. They were tested for normal quality control tests like disintegration, weight variation, hardness and friability. The drug release study is carried out for 2hrs in 0.1N HCl and followed with 1hr in 6.8 phosphate buffer. The present work of Serratiopeptidase was formulated as delayed release tablet which significantly increase the small intestinal absorption and the drug was targeted to small intestinal regions. This was achieved by enteric coating of tablets by simple standard pan coating method. Serratiopeptidase were formulated using HPMC phthalate as enteric coating polymer in different concentrations to optimize delayed drug release profile and to target the drug release in the small intestine regions. The present work was made to develop enteric coated tablets containing Serratiopeptidase tablets were made by direct compression method. While concluding the best formulation among the six F1 formulation shows 99.94% drug release than the all other formulations.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Serratiopeptidase tablets ; Formulation ; Evaluation |
| Subjects: | PHARMACY > Pharmaceutics |
| Depositing User: | Devi S |
| Date Deposited: | 11 Jun 2019 09:46 |
| Last Modified: | 13 Jun 2019 00:43 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10598 |
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