Senthil Kumar, S (2016) Study of hsCRP levels in Osteoarthritis Knee with Clinical and Radiological Correlation. Masters thesis, Madras Medical College, Chennai.
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Abstract
INTRODUCTION: Osteoarthritis of knee joint is a chronic degenerative disease affecting the elderly. Although it is known as degenerative disease without inflammation some degree inflammation of synovium and cartilage do occur. These inflammatory changes may have elevation in inflammatory markers such as hsCRP. With advent of newer methods of detecting CRP such as high sensitive C -reactive protein these minimal inflammatory states can be detected. With background of pain symptoms and radiological progression, estimation of hsCRP levels in patients are studied to establish a correlation among inflammatory markers and pain symptoms and or radiological signs such as X-ray changes. MATERIALS AND METHODS: A total of 60 patients with clinical evidence of osteoarthritis of knee are selected and subjected to our study all patients are enrolled with their consent and after ethical clearance, study conducted. History taken in accordance of symptom duration and pain scaling done by visual analog scale (VAS). From history other chronic condition such as inflammatory arthritis, cardiovascular disease, diabetes etc are rule out. Patient had their BMI calculated. Examination of knee done in particular for tenderness, deformity, effusion and restriction of movements. Radiological categorization of knee joint disease is done by Kellgren - Lawrence grading system (0-4) but our patients are more than grade 2 as per inclusion criteria. Blood Sample collected and centrifuged for plasma separation. From the sample of FFP collected hsCRP levels estimated by ELISA method. Statistical Method: SPSS, one way ANOVA method, Pearson correlation coefficient. RESULTS AND CONCLUSION: From the statistical analysis following were found out 1. Osteoarthritis patient had their hsCRP levels modestly elevated than general population but less than inflammatory arthritis. 2. Pain symptoms and pain scale strongly correlated with hsCRP levels. 3. BMI had minimal correlation with hsCRP levels. 4. Radiological progression does not seen to correlate with hsCRP level of the patient one way ANOVA (p > 0.05). 5. Knee Osteoarthritis patient who had local inflammatory symptoms that is pain had higher inflammatory marker that is hsCRP which can be used as a marker of disease progression.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.201311011 |
| Uncontrolled Keywords: | hsCRP ; Osteoarthritis Knee ; Clinical ; Radiological Correlation. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 06 Feb 2019 12:10 |
| Last Modified: | 06 Feb 2019 12:10 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10529 |
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