Betaine Therapy and Its Influence on Outcome of Acute on Chronic Alcoholic Liver Disease

Venkatakrishnan, R (2016) Betaine Therapy and Its Influence on Outcome of Acute on Chronic Alcoholic Liver Disease. Masters thesis, Madras Medical College, Chennai.


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Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide and can lead to fibrosis and cirrhosis. The spectrum of disease ranges from fatty liver, alcoholic hepatitis which leads to fibrosis, cirrhosis, and finally to hepatocellular carcinoma. With increasing consumption of alcohol and increasing burden of chronic liver disease patients in India and across the world, research efforts have only managed to raise more questions than provide answers to the demands of both logic, science and clinicosocial burden of patients with this disease. Betaine is a drug that acts as a methyl group donor whereby it reduces the fatty burden and interrupts the pathogenic process in non alcoholic fatty liver disease. Its use has yet to be explored on alcoholic liver disease. In this study forty patients with acute hepatitis with underlying alcoholic chronic liver disease are randomized into two equal groups, and one group given six gram per day of betaine for twelve weeks and liver function; renal function; clotting ability; and blood counts were monitored. Patients were also subjected to pre and post trial upper gastrointestinal endoscopy. The results were compared. CONCLUSION: No significant difference was found in any of the parameters between the two groups. Thus betaine had no value in acute on chronic alcoholic liver disease.

Item Type: Thesis (Masters)
Additional Information: Reg.No.201311024
Uncontrolled Keywords: Betaine ; alcohol ; alcoholic liver disease ; cirrhosis ; acute hepatitis ; chronic liver disease ; fatty liver.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 06 Feb 2019 07:10
Last Modified: 06 Feb 2019 07:10

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