Dilip Kumar, R (2016) TIMI Score in Acute ST Elevation Myocardial Infarction and Its Correlation with Single Quantitative Troponin T and Ejection Fraction < 40%. Masters thesis, Kilpauk Medical College, Chennai.
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Abstract
BACKGROUND: Acute Coronary Syndrome (ACS) remains the top killer in the world in the world in the last 3-4 decades. ST Elevation Myocardial Infarction (STEMI) is a part of ACS that has a very high short term as well as long term mortality. TIMI score for STEMI is usually calculated at the time of admission. accurately predicts the mortality of patients at 30 days . It is also said that Quantitative Troponin T levels and Ejection Fraction < 40% are predictors of mortality as they represent the Infarct Size approximately. In our study , We have tried to correlate the TIMI score at the time of admission in STEMI patients with Single Quantitative Troponin T at 12 hours post admission and Ejection Fraction < 40% at 48 hours post admission. We have also tried to correlate Quantitative Troponin T at 12 hours with EF < 40% at 48 hours. The main advantage of using TIMI score is that it is entirely clinical and uses only bedside data and ECG. We also took effort to find out whether Smoking and Dyslipidemia can affect TIMI score, Troponin T or EF. AIMS AND OBJECTIVES: AIMS OF THE STUDY: To assess the TIMI score for acute STEMI and its relationship with Quantitative Troponin T and LV Ejection Fraction. OBJECTIVES: 1. To assess the relationship between TIMI score for acute STEMI and Single Quantitative Troponin T at 12 hours following admission. 2. To assess the relationship between TIMI score for acute STEMI and EF < 40% at 48 hours post admission. METHODS: This is a Cross Sectional Study (Descriptive) conducted during December 2014 to May 2015 . Our sample size is 52 patients presenting with STEMI in KMCH casualty during this period. STEMI is diagnosed using WHO criteria and then TIMI score was calculated immediately after diagnosing STEMI along with other relevant clinical data. All patients were treated with thrombolysis just after admission. Lipid profile was done in fasting state the next day morning for all patients. Blood for Troponin T (Quantitative) was taken at 12 hours post admission and determined using ECLIA (Electrolchemiluminescent assay) method. Ejection Fraction was calculated using 2D Echocardiogram 48 hours post admission. RESULTS: There was a significant Correlation between TIMI score at admission and Quantitative Troponin T at 12 hours post admission (p = 0.005). There was a significant association between TIMI score at admission and EF < 40 % at 48 hours (p = 0.005). There was also significant association between Troponin T at 12 hours and EF < 40% at 48 hours (p = 0.005). There was no statistically significant correlation between Smoking or dyslipidemia and TIMI score, Troponin T or EF. CONCLUSION: Thus, TIMI score at the time of admission not only predicts the mortality of patients at 30 days but can also be used to predict the Troponin T levels at 12 hours and patients with EF < 40% at 48 hours at the time of admission itself. Neither Smoking nor dyslipidemia affects TIMI score, Troponin T at 12 hours or EF at 48 hours.
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.201311152 |
| Uncontrolled Keywords: | Acute Coronary Syndrome (ACS) ; Thrombolysis In Myocardial Infarction (TIMI) ; ST Elevation Myocardial Infarction (STEMI) ; TIMI score ; Troponin T ; Ejection Fraction ; Smoking ; Dyslipidemia. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 06 Feb 2019 05:53 |
| Last Modified: | 06 Feb 2019 05:53 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10515 |
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