Clinical Profile of Leptospirosis with Special Mention to its Multiorgan Involvement in Kilpauk Medical College Hospital

Ibrahim, Sameem Kan (2016) Clinical Profile of Leptospirosis with Special Mention to its Multiorgan Involvement in Kilpauk Medical College Hospital. Masters thesis, Kilpauk Medical College, Chennai.

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BACKGROUND: Leptospirosis has been considered an infrequent zoonoses in India for a long period of time.But for the past two decades there has been a steady increase in incidence of leptospirosis cases in many Indian states particularly Kerala, Gujarat and Tamil Nadu. Hence this study on the clinical profile of Leptospirosis and its pattern of multiorgan involvement was carried out and the results were analysed. AIM OF THE STUDY: 1. To study and analyse the clinical profile of leptospirosis. 2. To study the incidence of multiorgan involvement of leptospirosis. METHODS: This is a cross sectional descriptive study carried out in KMCH during the period ranging from Jan 2015 to August 2015.Data for the proposed study was collected in a pre tested proforma which includes various socioeconomic parameters like age, sex, occupation etc. Clinical, Biochemical and hematological profile of these patients were obtained from the date of admission, during the hospital stay. The analysis of the data was made on the basis of important statistical parameters like the Mean, Standard deviation, Standard error, T-test and proportion test where applicable RESULTS: The various epidemiological factors as well as pattern of multiorgan involvement which frequently manifested as Acute Hepatitis and Acute Renal Failure were studied and correlation between the various studies were analysed in depth. The most common clinical signs were conjuctival congestion (83.6%), Hepatomegaly (88%) followed by Icterus (58.2%). Among the 67 patients included in the study 16 cases (23.9%) had no complications whereas 76% (51 cases) developed various complications. Notable among them was ARF (46.3%), Hepatitis (58.2%). The occurrence of myocarditis was rare (3%). CONCLUSION: Thus leptospirosis proves to be an important health problem in Indian subcontinent particularly the southern states and hence early diagnosis and initiation of treatment is important in preventing morbidity and mortality. More emphasis should be laid on preventive measures that would decrease the incidence of the disease.

Item Type: Thesis (Masters)
Additional Information: Reg.No.201311153
Uncontrolled Keywords: Leptospirosis ; Microscopic slide agglutination test (MSAT) ; Acute renal failure (ARF) ; Hepatitis.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 06 Feb 2019 05:31
Last Modified: 06 Feb 2019 16:46

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