Dyslipidemia in Subclinical Hypothyroidism

Saranya, Masilamani (2016) Dyslipidemia in Subclinical Hypothyroidism. Masters thesis, Kilpauk Medical College, Chennai.


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BACKGROUND: Subclinical form of hypothyroidism which is mostly asymptomatic and diagnosed by laboratory investigations is on emerging trend in past few decade. The underdiagnosis of SCH in the community may lead to various complications like adverse lipid profile abnormalities, cardiac dysfunction, infertility, neuropsychiatric disturbances and its conversion to overt hypothyroidism. So early diagnosis and prompt of patients may prevent its adverse complications. AIM OF THE STUDY: To Assess Lipid Profile Abnormalities in Patients Diagnosed with Subclinical Hypothyroidism. METHODS: This is a cross sectional study conducted during January 2015 and august 2015. Screening of patients attending medicine opd and other departments like general surgery , obstetrics and endocrinology op with features suggestive of thyroid dysfunction and on random basis for dyslipidemia in subclinical hypothyroidism using fasting TFT and lipid profile . Tests includes TSH , free T3, free T4, TGL , LDL, HDL, TC. Among 620 patients screened for thyroid dysfunction , 96 were positive for subclinical hypothyroidism. RESULTS: Lipid abnormalities were found to be present in patients with subclinical hypothyroidism with elevated total cholesterol and LDL levels and triglyceride levels. The rising TSH has significant correlation with total cholesterol and LDL levels. CONCLUSIONS: It is essential to screen long standing subclinical hypothyroidism patients for dyslipidemia. Early diagnosis and prompt treatment with levothyroxine might lower the elevated total cholesterol, LDL, triglyceride levels and prevent its associated cardiovascular morbidity.

Item Type: Thesis (Masters)
Additional Information: Reg.No.201311161
Uncontrolled Keywords: Subclinical hypothyroidism ; Thyroid stimulating hormone (TSH) ; TGL ; Low density lipoprotein (LDL) ; High density lipoprotein (HDL) ; Total cholesterol(TC).
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 06 Feb 2019 04:39
Last Modified: 06 Feb 2019 04:39
URI: http://repository-tnmgrmu.ac.in/id/eprint/10507

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