A Study on the Effect of Microcytic Anaemia on Hba1c Levels in Non Diabetic Individuals in Government Royapettah Hospital, Chennai

Swetha, S (2016) A Study on the Effect of Microcytic Anaemia on Hba1c Levels in Non Diabetic Individuals in Government Royapettah Hospital, Chennai. Masters thesis, Kilpauk Medical College, Chennai.

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Abstract

BACK GROUND: Protein glycation is a spontaneous reaction that happens as a function of the circulating blood sugar levels. The major form of protein glycation with a clinical consideration is glycated hemoglobin (HbA1c). The HbA1c fraction being abnormally elevated in chronic hyperglycaemic diabetic patients is used as a marker of glycemic control. However, altered HbA1c levels have been documented in anaemic patients without any history of diabetes and the reports on the effects of iron deficiency anemia on HbA1c levels are inconsistent. This study was henceforth conducted to establish the effect of microcytic hypochromic anemia on hba1c levels in non diabetic individuals. AIM OF THE STUDY: The aim of this study was to determine the effect of microcytic anemia on the HbA1c levels in non diabetic patients, so as to consider anemia as an important factor which influences the HbA1c levels, while monitoring the glycemic status of diabetics. METHODOLOGY: Fifty non-diabetic, anaemic patients and 50 age-matched healthy subjects were enrolled in this study. The patients who had glucose tolerance abnormalities (impaired glucose tolerance or diabetes mellitus), haemoglobinopathies, haemolytic anaemia, infestation, chronic alcohol ingestion and chronic renal failure were excluded from the study. Haematologic investigations were done and the fasting and postprandial glucose and HbA1c levels were measured in all the subjects. RESULTS: The mean HbA1c (5.32 ± 0.3%) level in the patients with IDA was higher than that in the control group (5.14% ± 0.5) (p < 0.05). There were no differences in the levels of fasting and postprandial glucose between the IDA and the control groups (p > 0.05). The haemoglobin, fasting and postprandial glucose, and the HbA1c levels were normal in the control group (p > 0.05). CONCLUSION: HbA1c is not affected by the blood sugar levels alone, and there are various confounding factors when HbA1c is measured, especially that of microcytic anemia, probably due to iron deficiency which is very common in this part of thr world. It is hence prudent to rule out anemia especially microcytic anemia before making a therapeutic decision, based on the HbA1c levels.

Item Type: Thesis (Masters)
Additional Information: Reg.No.201311165
Uncontrolled Keywords: Microcytic anemia ; Hemoglobin A1c ; HbA1c ; Glycated hemoglobin ; Diabetes.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 06 Feb 2019 03:07
Last Modified: 06 Feb 2019 03:07
URI: http://repository-tnmgrmu.ac.in/id/eprint/10503

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