Clinico-Haematological profile of Pancytopenia

Alex Mathew, D (2016) Clinico-Haematological profile of Pancytopenia. Masters thesis, Tirunelveli Medical College, Tirunelveli.


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INTRODUCTION: Pancytopenia is an important clinico-haematologic entity with varying trends in its clinical presentation, treatment approaches and outcome. It is not a disease entity, but a triad of findings that results from a wide number of possible disease processes that primarily or secondarily involve the bone marrow. The severity of pancytopenia and the underlying pathology plays an important role in determining the treatment approach and response of patient to same. In India, the causes of pancytopenia are not well defined and the present study has been undertaken in the hope that this data will help in planning the diagnostic and therapeutic approach in patients with pancytopenia. AIM OF THE STUDY: 1. To study various clinical presentations in pancytopenia. 2. To evaluate various haematological parameters and to arrive at a diagnosis. MATERIALS AND METHODS: Patients admitted in General Medicine Department of Government Medical College, Tirunelveli fulfilling criteria for pancytopenia ( presence of all 3 of the following:- Haemoglobin < 10gm/dl, Total WBC count < 4,000 / μL, Platelet count < 1,00,000/ μL with the exception of those under the age of 13 years and those undergoing chemotherapy) were evaluated clinically. Adequate haematological investigations and other relevant investigations were carried out including peripheral smear and bone marrow examination as part of the workup. Study Design & Period: Cross sectional observational study with study period as July 2014- June 2015. RESULTS & CONCLUSIONS: Hypersplenism was found to be the most common cause (23.33%) for pancytopenia with young people contributing to the major bulk of pancytopenia cases followed by megaloblastic anemia (16.67%). Fever (63%), breathlessness (42%) and dependant oedema (40%) were the predominant clinical presentations; and pallor (95%), oedema (50%), splenomegaly (32%) and hepatomegaly (22%) were the predominant clinical findings. Dimorphic blood picture (45%) was predominantly seen in peripheral blood. Vitamin B12 deficiency was attributed to be the cause of 60% of cases of megaloblastic anemia.

Item Type: Thesis (Masters)
Additional Information: Reg.No.201311360
Uncontrolled Keywords: Pancytopenia ; hypersplenism ; megaloblastic anemia ; pallor ; dimorphic anemia.
Subjects: MEDICAL > General Medicine
Depositing User: Subramani R
Date Deposited: 06 Feb 2019 02:00
Last Modified: 06 Feb 2019 02:00

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