Sountharya, N (2016) A Comparative study of Plasma Fibrinogen in Male and Female patients with Coronary Artery Disease. Masters thesis, Tirunelveli Medical College, Tirunelveli.
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Abstract
BACKGROUND: Coronary artery disease is the largest killer in developed countries and is rapidly becoming one in developing countries. Conventional risk factors do not explain all cases of coronary artery disease. The increasing risk of coronary artery disease among young suggests the possible role of non-conventional risk factors. In recent years, the role of plasma fibrinogen as an independent cardiovascular risk factor has been increasingly recognized. Thrombosis, endothelial dysfunction and inflammation are recognized as mechanism of atherosclerotic complications. Fibrinogen is a major determinant of fibrin formation, blood viscosity and platelet aggregation and thus enhances the thrombogenic tendency. There is paucity of data on the emerging risk factors for coronary artery disease in Indian population especially women. Hence this present study is undertaken to evaluate the association of plasma fibrinogen in coronary artery disease patients. OBJECTIVE: To estimate the level of plasma fibrinogen in both male and female patients presenting with acute myocardial infarction and to assess the association between plasma fibrinogen and coronary artery disease and compare between male and female patients. MATERIALS AND METHODS: Source of Data: Cases for the present study were selected randomly from the inpatients of ICCU ward, and male and female medical wards admitted with acute myocardial infarction, in Tirunelveli medical college hospital, Tirunelveli. Period of Study: August 2014 to August 2015. Study Design: Prospective cross sectional study. Sample Size: 70 patients, 35 Males and 35 Females. METHOD OF STUDY: An informed consent taken from all subjects of the study. A detailed clinical history was taken and a thorough clinical examination and the required laboratory investigations were done. CPK-MB, Troponin-T, ECG, Plasma fibrinogen were taken in all subjects. The details collected from each patient was entered in the proforma. The data were analyzed and the results were compared. RESULT: In this study of 70 patients involving 35 males, 35 females it was found that plasma fibrinogen levels were high in both male and female patients with coronary artery disease and the association was found to be statistically significant. CONCLUSION: The findings from our study provide evidence that plasma fibrinogen is associated with excess risk of CAD in women. But, the association between plasma fibrinogen and cardiovascular risk does not establish a cause-effect relationship. Further large scale studies are needed to establish the causal relationship of fibrinogen to coronary artery disease in both the sexes.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Coronary Artery Disease ; Plasma Fibrinogen ; Female. |
| Subjects: | MEDICAL > General Medicine |
| Depositing User: | Subramani R |
| Date Deposited: | 06 Feb 2019 00:50 |
| Last Modified: | 06 Feb 2019 00:50 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10490 |
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