Jothi Ganesh, R (2016) Morphometric Study of Aorta, Pulmonary Trunk and Ductus Arteriosus with Gross and Histological Correlations in Human Fetuses of Tamilnadu Population. Masters thesis, PSG Institute of Medical sciences and Research, Coimbatore.
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Abstract
INTRODUCTION: Materno – Fetal healthcare is one of the most rapidly evolving fields in medicine focusing on the medical and surgical management of high-risk pregnancies. Basic researches carried out in the fetus leads to an in-depth understanding of its structural and functional aspects eventually for the better care for pregnant mother and her growing fetus. AIM OF THE STUDY: To study the morphometric details of Aorta, Pulmonary Trunk and Ductus Arteriosus in the human fetuses between 14th to 36th week gestation: In-utero ultrasonographic study with histo-topographical correlations in aborted fetuses. OBJECTIVES: 1. To quantify the developmental of the Aorta, Pulmonary Trunk, and Ductus Arteriosus and define the normal growth patterns using ultrasonographic measurement. 2. To study the histological changes in the great arterial vessels using Hematoxylin-Eosin & Verhoeff- Van Gieson staining techniques. 3. To identify the topographical relationship of great arterial vessels using fetal dissection method. 4. To include the expected incidental findings of the study. MATERIALS AND METHODS: To study the morphometric details of Aorta, Pulmonary Trunk and Ductus Arteriosus in the human fetuses between 14th to 36th week gestation: In-utero ultrasonographic study with histo-topographical correlations in aborted fetuses100 samples were collected from PSG Hospitals, out of which 50 aborted fetuses and 50 ultra-sonographic images of fetuses aged between 14-36 weeks of gestation was collected. RESULTS & DISCUSSION: In the present study mean aortic and pulmonary internal diameters were 2.3, 2.5 mm respectively for 14-20 weeks of gestation. From 21-30 weeks it was 3.4, 3.7 and for 31-36 weeks it is 5.7 and 6.5 mm. The association of gestational age with tunica media thickness of aorta and pulmonary trunk showed high correlation with a r value of 0.926 & 0.914 The association of gestational age with thickness of ductus arteriosus showed moderate correlation with a r value of .828. Histological basis of ductal closure by formation of the intimal mounds and interruption of internal elastic lamina (around 20th week) can further be extended to an ultra structural level. CONCLUSION: Measurements of Aorta, Pulmonary Trunk and Ductus arteriosus taken in ultrasound addressed the paucity of quantitative anatomical data concerning the growth of these vessels in our Tamilnadu population and as intended fulfilled the aim of study. Based on the study findings, it is advised to visualize the outflow tracts using the extended basic cardiac examination which is much critical for evaluation of congenital heart diseases and outflow tract disorders whenever feasible. An attempt to correlate the growth parameters with histological basis and topographical relations as undertaken by the measurement of tunica media thickness showed high correlation with regard to gestational age for Aorta and Pulmonary Trunk. Incidental findings of ductal closure by formation of the intimal mounds and interruption of internal elastic lamina can further be extended to an ultra structural level. Influence of the left recurrent laryngeal nerve on the ductal musculature could have been addressed using on immunohistochemical techniques. Materno-Fetal health care as addressed through this study will be explored more by the researcher in the future....
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.201333252 |
| Uncontrolled Keywords: | Materno –Fetal Healthcare (MFH) ; Morphometrics ; Ultrasonography (USG). |
| Subjects: | MEDICAL > Anatomy |
| Depositing User: | Devi S |
| Date Deposited: | 30 Jan 2019 17:25 |
| Last Modified: | 30 Jan 2019 17:25 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10443 |
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