Nithyamala, I (2013) Anti inflammatory and Analgesic activity of Karuvilanchi Ver Chooranam (Smilax zeylanica Linn.) and Diuretic activity of Jalamanjari Chendooram. Masters thesis, Government Siddha Medical College, Chennai.
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Abstract
KARUVILANCHI VER CHOORANAM: The herb Karuvilanchi ver was collected from Kanyakumari (Dt), Tamil Nadu and it is then purified, powered and stored. This drug was subjected to different studies by the author. “Karuvilanchi ver Chooranam” was selected for this dessertation study to evaluate the Anti inflammatory and analgesic activity, and also to prove its efficacy and safety in Osteoarthritis. The information about the drug, was collected from various text books, Literature were referred. From these informations, the author came to an idea about the drug and its efficacy on Osteoarthritis. A brief description about botanical aspect of the herb Karuvilanchi ver and its identifying characters and phytochemical analysis reports were given. The pharmacological analysis revealed that the drug has got significant Anti inflammatory and analgesic activity. In clinical study, the drug has showed remarkable improvement in 78% of cases. The patients responded well from the commencement of the treatment and there were no adverse effects during the course of the clinical trial. This present study suggests that Karuvilanchi ver Chooranam has the significant medicinal value against the disease osteoarthritis without any adverse effect. CONCLUSION: The trial drug “Karuvilanchi ver Chooranam” has been selected and its efficacy was analyzed in the treatment of Osteoarthritis. The plant is readily available and preparation is also simple. The trial drug is not only efficient, but also cost effective. The results of the present pharmacological study suggest that Karuvilanchi ver chooranam have significant anti-inflammatory effect against formalin induced paw oedema. The drug shows good Anti inflammatory and analgesic activity. During the entire clinical trial no adverse effects resulted. From all the above observations, I conclude that the trial drug “Karuvilanchi ver chooranam” (Smilax zeylanica,) gives a new hope in the Osteoarthritis Treatment. JALAMANJARI CHENDOORAM: The poly mineral drug Jalamanjari Chendooram was prepared as per the traditional way. The author subjected the drug to various studies. Jalamanjari Chendooram was selected for this study to establish the safety and efficacy of the drug as a diuretic. The information about the drug, was collected from various text books, Literature were referred. From them, the author came to an idea about the drug and its efficacy as a diuretic. A brief description about Siddha aspect of the minerals used in the preparation of Jalamanjari Chendooram characters was given. Acute and Sub acute toxicological studies show strong evidence of the nontoxic effect of the Jalamanjari Chendooram. The results showed Jalamanjari Chendooram is safe and efficient diuretic Siddha medicine. The pharmacological analysis showed that the drug has got significant diuretic activity. In clinical study, the drug has showed improvement in 70% of cases. The patients responded well from the beginning of the treatment and there were no adverse effects during the entire clinical study. This present study suggests that Jalamanjari Chendooram has remarkable medicinal value as a diuretic. CONCLUSION: Jalamanjari Chendooram is a unique type of medicine, which is made up by a special type of preparation method erippu chendooram in siddha system which is written by the great Siddhar Yoogi muni in ‘Yoogi karisal 151’. Literature survey, Chemical analysis, Physico chemical analysis, showed the efficacy of Jalamanjari Chendooram as a diuretic. Since many of the constituents in the medicine according to the literature review has got a diuretic property Jalamanjari Chendooram is one among the gifted medicines in the siddha system. The finding of the pre clinical study suggests that Jalamanjari Chendooram is an effective diuretic. Jalamanjari Chendooram had remarkable effect in increasing the 24hrs urine volume in patients before and after treatment. In clinical trials, the drug shows the significant improvement in 70% of patients Thus the siddha science based Jalamanjari Chendooram had been proved by the modern scientific parameters as an efficient diuretic.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Anti inflammatory and Analgesic activity ; Karuvilanchi Ver Chooranam ; Smilax zeylanica Linn ; Diuretic activity ; Jalamanjari Chendooram. |
| Subjects: | AYUSH > Gunapadam |
| Depositing User: | Subramani R |
| Date Deposited: | 07 Jan 2019 03:34 |
| Last Modified: | 08 Jan 2019 10:14 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10364 |
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