Leelavathi, D (2013) Anti histamine, Anti inflammatory, Anti microbial activity of Aivaeli Samoola Chooranam and Navachara Chunnam for its Naturally Curing Polycyctic Ovarian Syndrome. Masters thesis, Government Siddha Medical College, Chennai.
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Abstract
PATHAARTHA GUNA VILAKKAM: The plant Diplocyclos palmatus (Aivaeli) is selected from the Siddha text 'Pathaartha guna vilakkam’ for the evaluation of its therapeutic efficacy on Karappan(Eczema). The dissertation has started with an introduction in which Siddha fundamental theory behind selection of drugs for a disease, essentiality of Phytotherapy, the need for preclinical and clinical study on Aiveli for Karappan is signified. The plant of Diplocyclos palmatus (Aivaeli) had been collected from Anthiyur Hills, Erode district, Tamilnadu and authenticated by experts. Drug review disclosed the collection of Botanical aspect, Siddha aspect and Modern scientific aspects about the trial drug. Disease review explored the collection of siddha and modern literature about Eczema. The drug was subjected to step wise procedure of analysis like pharmacognostic study, physicochemical, phytochemical, chemical analysis to account the creditability of drug. Toxicological studies comprised of the evaluation of non-toxic dosage, acute toxicity on Swiss albino mice according to OECD guidelines. Pharmacological study revealed the Anti-histamine, Anti-inflammatory, Anti-microbial activity of Aivaeli Samoola Chooranam. Open clinical trial was conducted in 50 patients at Arignar Anna Government Hospital of Indian Medicine and Homeopathy, Chennai. The drug has shown significant improvement in Eczema patients. Overall result revealed that out of 50 patient 37 patient had marked response, 7 patient had moderate response, 4 patient had mild response and 2 patient had poor response. There were no new or unexpected safety events noticed during the course of the treatment. The final Discussion and conclusion chapters analyzed the dissertation. The conclusion chapter also provides a nutshell impact created by the study on Aiveli and made Aivaeli samoola chooranam as a scientifically proven drug of choice for Karappan(Eczema) to the medical society. CONCLUSION: The plant Diplocyclos palmatus (Aivaeli) is selected from the Siddha text 'Pathaartha guna vilakkam’ for the evaluation of its therapeutic efficacy on Karappan(Eczema). The plant of Diplocyclos palmatus (Aivaeli) authenticated by experts was subjected to step wise procedure of analysis like pharmacognostic study, physicochemical, phytochemical, chemical analysis to account the creditability of drug. From the preliminary chemical analysis ,we came to know that the trial drug have Amino acid, Phosphate, Sulphate, Chloride, Iron, Calcium, Zinc, Alkaloids, Tannic acid. Zinc has potent wound healing activity. Zinc in Aiveli samoola chooranam might be the reason for its action in healing ulcers seen in Eczema. Toxicological studies comprised of the evaluation of non-toxic dosage, acute toxicity on Swiss albino mice according to OECD guidelines. Pharmacological study revealed the Anti-histamine, Anti-inflammatory, Anti-microbial activity of Aivaeli Samoola Chooranam. The biologically active Aivaeli Samoola chooranam inhibiting the histhamine induced contraction on isolated guinea pig ileum preparation. Thus, the Aivaeli Samoola chooranam confirms the antihistaminic effect in presence of agonist like histamine which justify the H1 antagonistic traditional claim of Aivaeli Samoola chooranam in siddha system of medicine. The antimicrobial activity of Aivaeli Samoola Chooranam was tested. The maximum inhibition zone was observed for the E.coli, S. typhi and Candida albicans 7-9mm at the concentration range of 25-100μg/ml. The drug has shown significant improvement in Eczema patients. Overall result revealed that out of 50 patient 37 patient had marked response, 7 patient had moderate response, 4 patient had mild response and 2 patient had poor response. There were no new or unexpected safety events noticed during the course of the treatment. From the above listed studies of Aiveli samoola chooranam, it can be concluded that the drug is safe and excellent medicine for management of Karappan. NAVACHARA CHUNNAM: The trial drug Navachara Chunnam is selected from the classical Siddha text Anubhoga Vaidhya Navaneetham for the evaluation of its therapeutic efficacy on Polycystic ovarian syndrome(Sudhagakatti). In the Introduction, the need to explore a new drug and the lacuna in present day management of PCOS is signified. In Drug review, Navacharam is viewed in the field of General characters, therapeutic action and its presence in Siddha formulations indicated for female reproductive disorders. The uniqueness of Chunnam medicines expounded by siddhars are highlighted. Disease review explored the collection of Siddha literature as well as present scientific view about PCOS. To standardize the drug, Physical and chemical study of the drug was done at SCRI, Arumbakkam, Chennai. Instrumental analysis for the drug was done at Anna University, Chennai. SEM analysis revealed the size of the drug particle is in Nanometer which implies that the drug could have potent drug delivery. FTIR analysis disclosed the presence of Phenolic groups which could act as an anti-oxidant and prevent classical risk factors of PCOS. . The results of ovulation effect in Rats revealed the significant influence at the dose level of 25mg/kg and this marked effect was ensured with the histological evaluation of uterus of experimental rats also. Hence it may be concluded that the Navachara Chunnam is an excellent traditional medicine in the treatment for anovulatory conditions like PCOS and the effect may be attributed to the elevation of the ovulation stimulatory hormones in animal models. In Clinical study, Open clinical trial was conducted in 44 patients at Arignar Anna Government Hospital of Indian Medicine and Homeopathy, Chennai. The drug has shown significant improvement in Polycystic ovarian patients. The final Discussion and conclusion chapters analyzed the dissertation. The conclusion chapter also provides a discussion of the verification and validity of the research results carried out. The most vital part of some experience of the findings in the dissertation is also discussed and thereafter invites the reader to further studies and future research possibilities.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Anti histamine ; Anti inflammatory ; Anti microbial activity ; Aivaeli Samoola Chooranam ; Navachara Chunnam ; Naturally Curing ; Polycyctic Ovarian Syndrome. |
| Subjects: | AYUSH > Gunapadam |
| Depositing User: | Subramani R |
| Date Deposited: | 07 Jan 2019 03:33 |
| Last Modified: | 08 Jan 2019 09:36 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10363 |
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