Kavitha, P (2013) Anti Ulver activity of Panai Poo Chooranam (Borassus flabellifer, Linn) and Hepatoprotective activity of Arithiraadhi Chooranam. Masters thesis, Government Siddha Medical College, Chennai.
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Abstract
PANAI POO CHOORANAM: The herb Panai poo was collected from Soorapalli, Salem (Dt) and purified then powered and stored. This drug was subjected to various studies by the author. Panai poo Chooranam was selected for this study to evaluate the Anti – ulcer activity, and to prove its efficacy and safety in peptic ulcer disease. To collect the information about the drug, various text books, Literature were referred. From them, the author came to an idea about the drug and its efficacy on Peptic ulcer. A brief description about botanical aspect of the herb Panai poo and its identifying characters and Phyto chemical data’s were given. The pharmacological analysis showed that the drug has got significant Anti ulcer activity. In clinical study, the drug has showed marked improvement in 76% of cases. The patients were responding well from the beginning of the treatment and no adverse effects were reported. This present study suggests that Panai poo Chooranam has the remarkable medicinal value against the disease Peptic ulcer without any adverse effect. CONCLUSION: The trial drug Panai poo chooranam (Borassus flabellifer Linn) was selected from the classical siddha text Gunapadam-Mooligai vagupu, Agathiyar gunavaakadam, for the evaluation of safety and efficacy in the management of Peptic ulcer disease. The trial drug was identified and authenticated by the botanist and Gunapadam experts. The physico chemical analysis result showed the pH of Panai poo chooranam is 6.6. So it neutralizes the acidic pH of gastric juice. The phyto chemical analysis result showed the presence of Tannins, triterpenes, steroids, glycosides, saponin and phenol. Previous studies about tannin proved that, it had the anti ulcer property. Hence the author concluded that Panai poo chooranam has anti ulcer property. The examination of acute toxicity carried out on mice indicated that Panai poochooranam has no toxicity when administered orally (up to 5g/kg). Toxicity study revealed the safety of the drug. Clinical trial results showed that 76% of patients were having improvement in the clinical features. The drug is easily available and preparation is very simple. The trial medicine is cost effective. No adverse effects were produced during the entire course of treatment. From these results the author has concluded that the drug “Panai poo chooranam” (Borassus flabellifer Linn) gives a new hope in the treatment of Peptic ulcer disease. ARITHIRAADHI CHOORANAM: The herbo mineral drug Arithiraadhi chooranam was prepared as per siddha literature. This drug was subjected to various studies by the author. Arithiraadhi chooranam was selected for this study to establish the safety and efficacy of its Hepatoprotective activity on Kamalai. To collect the information about the drug, various text books, Literature were referred. From them, the author came to an idea about the drug and its efficacy on Kamalai. Acute and Sub acute toxicological studies show strong evidence of the nontoxic effect of the Arithiraadhi chooranam. The pharmacological analysis showed that the drug has got significant Hepatoprotective Efficacy. In clinical study, the drug has showed improvement in 62% of cases. The patients were responding well from the beginning of the treatment and no adverse effects were reported. This present study suggests that Arithiraadhi chooranam has remarkable medicinal value against the disease Kamalai. CONCLUSION: The test drug Arithiraadhi chooranam was selected from the text “Sarabenthira vaithiya rathnavali” for the evaluation of safety, efficacy and therapeutic potential in Jaundice. All the raw drugs for the preparation of test drug were purchased from Tampcol raw drug store and authenticated, then subjected to preparation. Physico chemical anatysis, Chemical analysis, was showed that Curcuma longa, Picrorhiza kurao, and Terminalia chebula having phytochemicals which are hepatoprotecting agents. Tannins and flavanoids of Phyllanthus emblica contain anti oxidant and hepatoprotective properties. From the acute toxicity study as per OECD guideline 425, it was concluded that the test drug Arithiraadhi chooranam is a safety drug. Arithiraadhi chooranam did not produce any oral acute or sub acute toxicity in both female and male rats. Overall results suggest that Arithiraadhi chooranam is relatively safe in rats. The finding of the pre clinical study suggests that effective role of Arithiraadhi chooranam on jaundice.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Anti Ulver activity ; Panai Poo Chooranam ; Borassus flabellifer Linn ; Hepatoprotective activity ; Arithiraadhi Chooranam. |
| Subjects: | AYUSH > Gunapadam |
| Depositing User: | Subramani R |
| Date Deposited: | 07 Jan 2019 03:31 |
| Last Modified: | 08 Jan 2019 09:09 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10362 |
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