Sathyavathi, M (2013) A Study on Uthiravatha Suronitham (Rheumatoid Arthritis). Masters thesis, Government Siddha Medical College, Palayamkottai.
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Abstract
The disease Uthiravathasuroitham was comparatively studied with the disease Rheumatoid arthritis with reference to its etiology, pathogenesis and clinical features. Rheumatoid arthritis is the leading cause of chronic disability and permanent deformities in the 0.5%-1% population and only symptomatic relief is found. There is a need to evaluate the safe and effective drug for Rheumatoid arthritis. So SITHATHI ENNAI is given for purgation during the initiation of the treatment; Then MYELIRAGATHI ENNAI as internal medicine and VAENGAIPATTAI THYLAM as external medicine was selected and a clinical trial in Govt. Siddha Medical College, Palayamkottai was conducted with these drugs. For this 40 cases were selected in which12 were treated in Out-Patient ward and remaining 28 in In-Patient ward. The pre clinical studies of the trial drug were found to be encouraging. Pharmacological analysis of Myeliragathi ennai shows 1. significant analgesic action, 2. moderate Acute anti inflammatory action, 3. significant chronic anti inflammatory action, 4. Moderate antipyretic action. Pharmacological analysis of Vaengaipattai thylam shows • Moderate acute anti inflammatory action. The diagnosing criteria mainly Morning stiffness in joints, involvement of metacarpophalangeal joints, Joint pain (+), Swelling (+) are noted for the clinical assesment of the prognosis. The efficacy of medicine studied during the course of the research work. • Pain is reduced, • Swelling & Warmth is reduced, • Morning stiffness is reduced, • Patients where able to perform their daily activities with comfort. Fever is not found, in some cases with the episodes of fever periodically is also controlled. Since complementary therapies or manual therapies like massage, fomentation, exercises plays a significant role in treating UTHIRAVATHASURONITHAM some of the complementary therapies from siddha system are manipulated along with trial drugs depending upon the severity of the disease. Daily progress was observed to evaluate the efficacy. The results obtained were found to be auspicious. Particularly results by complementary therapies were found to be very auspicious. No adverse reactions were found. Hence the trial drug was found to be safe and effective. CONCLUSION: In this clinical study with SITHATHI ENNAI to balance the humors (vali, azal, iyam), the trial drugs “MYELIRAGATHI ENNAI” and “VAENGAIPATTAI THYLAM” were taken as Internal & External drug respectively for treating the disease UTHIRAVATHASURONITHAM. In the pre clinical study Pharmacological evaluation of the trial drugs shows: 1. Significant analgesic effect, 2. Significant acute anti inflammatory effect, 3. Moderate Antipyretic action. During the initiation of the clinical study, SITHATHI ENNAI administration in all the UTHIRAVATHA SURONITHAM patients showed miraculous progress in the patients .it also supported the further treatment too. The Overall results of efficacy of the trial drugs supported by the complementary therapies played an important role in reducing the clinical signs and symptoms like Joint pain, swelling, morning stiffness, movement restriction in this Clinical study were found to have marked effect in 20% cases, Moderate effect in 50% cases, Mild in 25% cases and no effect in 5% cases. The costs of the trial medicines were relatively economical. The raw drugs are easily available and the preparation was also convenient. No adverse effects and side effects were found clinically for the trial drugs. So the clinical effect of the trial drugs along with complementary therapies was found to be Moderate in treating the disease Uthiravatha suronitham (Rheumatoid arthritis).
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.32102008 |
| Uncontrolled Keywords: | Uthiravatha Suronitham ; Rheumatoid Arthritis ; Sithathi Ennai ; Myeliragathi Ennai ; Vaengaipattai Thylam. |
| Subjects: | AYUSH > Sirappu Maruthuvam |
| Depositing User: | Subramani R |
| Date Deposited: | 07 Jan 2019 03:25 |
| Last Modified: | 08 Jan 2019 14:51 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10356 |
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