Geetha, K (2011) Serum Paraoxonase activity in the Chronic Kidney Disease. Masters thesis, Stanley Medical College, Chennai.
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Abstract
INTRODUCTION Chronic Kidney Disease (CKD) is a global threat to health in general and for developing countries in particular because therapy is expensive and life long. CKD, encompasses a spectrum of different pathophysiological processes associated with abnormal kidney function and a progressive decline in Glomerular Filtration Rate (GFR). CKD usually has a gradual onset and in many cases progresses inexorably to a critical state – end stage renal disease (ESRD), in which the patient’s survival requires the initiation of renal replacement treatment, either by dialysis or renal transplantation. The prevalence of CKD is increasing among the different population of the world. According to various studies, the incidence and prevalence of CKD in India is ~ 0.78%. The domiciliary screening programme for CKD in South India has reported the prevalence of CKD (Stage 5) as 870 per million population (pmp). CKD with its multitude of complications and devastating outcomes leads to a significantly higher risk for Cardiovascular Disease (CVD) and all cause mortality in an individual. Kidney disease is both a cause and consequence of Cardiovascular Disease. All CKD patients irrespective of the underlying etiology, are at increased risk of CVD including coronary heart disease, cerebrovascular disease, peripheral vascular disease and heart failure. From the mortality stand point, it is not progression to kidney failure is more concerning in CKD patients, but progression to CVD. AIM & OBJECTIVE : The aim of this study is to determine the Serum PON activity in CKD patients and to compare the results with the healthy control subjects. The objective of this study is - to analyze the Serum PON activity and Lipid profile in CKD patients for predicting the atherogenic risk in these patients & to intervene earlier in preventing Cardiovascular complications. CONCLUSION : This present study, shows the involvement of PON in the excessive LDL peroxidation noticed in uremia. This study presents a potential explanation of accelerated atherosclerosis in CKD. There is a significant decrease in PON activity in the CKD patients and thus the decrease of its anti atherogenic properties in renal failure could be an important factor in premature vascular aging. The introduction of PON is a welcome event and based on the results obtained, the present study supports the previous studies that PON is a useful marker for the early diagnosis of atherosclerosis in CKD patients.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Serum Paraoxonase activity in the Chronic Kidney Disease. |
| Subjects: | MEDICAL > Biochemistry |
| Depositing User: | Subramani R |
| Date Deposited: | 07 Jul 2017 00:53 |
| Last Modified: | 07 Jul 2017 03:31 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/1027 |
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