Loganathan, Pon (2018) An Open Clinical Study of Siddha Drugs Elathy Chooranam (Internal) and Pathirasara Virana Poochu Thailam (External) in the treatment of Silaipun (Varicose Ulcer). Masters thesis, Government Siddha Medical College, Chennai.
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Abstract
The disease silaipun was taken for the clinical study with Elathy Chooranam as internal medicine and Pathirasara virana poochu thailam as external application. For the clinical study, 40 cases were selected based on the approved protocol. The trial was approved by the Institutional Ethical Committee (IEC) (Date of IEC Approval & its Number; NIS/IEC/2016/11-11/14.10.2016). The trial was registered in Clinical Trial Registry of India (CTRI/2018/04/013087). Hence the study is safely executed on patients and there was no adverse drug reactions noted during the study period. Out of the 40 cases, 20 cases were treated in OPD and remaining 20 cases were treated in IPD of Ayothidoss Pandithar Hospital of National Institute of Siddha, Chennai-47. The detailed study on silaipun with reference to its aetiology, pathogenesis, investigations, clinical features, diagnosis and treatment with trial drugs was done. The outcome results of my study was clinically observed by Venous Clinical Severity Score (VCSS) that is 32.5% of cases had shown good improvement, 12.5% of cases had shown moderate improvement, 37.5% of cases had shown mild improvement and remaining 17.5% had shown poor improvement. CONCLUSION: This clinical study validated the Siddha herbal formulation of the trial drug “Elathy Chooranam” is efficacy to Varicose ulcer patients. It was found to be effective on silaipun patients in reducing clinical signs and symptoms like pain, itching and size of the ulcer. The literature evidence for this drug is Siddha vaidhya thirattu which is well-known Shasthric preparation. In this study, no adverse reactions were reported. Hence, it is concluded that the trial drugs are clinically safe. The cost of the trial medicines are low. These drugs are easily available and the dosage is also convenient. The quantitative outcome of VCSS is statistically significant between the commencement and end of the treatment i.e from 12.15 ± 2.92 to 6.63 ± 4.14. The qualitative outcome shows there is 32.5% of cases shown good improvement, 12.5% of cases shown moderate improvement, 37.5 % shown mild improvement and 17.5% of cases shown poor improvement.
| Item Type: | Thesis (Masters) |
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| Additional Information: | (Reg.No: 321513204) |
| Uncontrolled Keywords: | Open Clinical Study of Siddha Drugs ; Elathy Chooranam ; Pathirasara Virana Poochu Thailam ; treatment ; Silaipun Varicose Ulcer. |
| Subjects: | AYUSH > Sirappu Maruthuvam |
| Depositing User: | Subramani R |
| Date Deposited: | 29 Dec 2018 11:12 |
| Last Modified: | 29 Dec 2018 11:12 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10257 |
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