Lalitha, S (2018) An open clinical trial of siddha drugs Parangipattai Chooranam (Internal) and Sangamver thylam (External) in the treatment of Kaalanjagapadai (Psoriasis). Masters thesis, National Institute of Siddha, Chennai.
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Abstract
The disease Kaalanjaga padai was taken for the clinical study with Parangipattai Chooranam as internal medicine and Sangamver Thylam as external application. For the clinical study, 40 cases were selected based on the approved protocol. The trial was approved by the Institutional Ethical Committee (IEC) (Date of IEC Approval & its Number:NIS/IEC/2016/11/16/14.10.2016). The trial was registered in Clinical Trial Registry of India (CTRI REF/2018/02/017568) Hence the study is safely executed on patients and there was no adverse drug reactions noted during the study period. The detailed study on Kaalanjaga padai with reference to its aetiology, pathogenesis, investigations, clinical features, diagnosis and treatment with trial drugs was done. The outcome results of my study was clinically observed by PASI SCORE that is 52.5% of cases had shown good improvement, 32.5% of cases had shown moderate improvement and remaining 15% of cases had shown mild improvement. CONCLUSION: This clinical study validated the Siddha herbal formulation of the trial drug Parangipattai Chooranam is efficacy to human psoriatic population. It was found to be good resulting on Kaalanjaga padi patients in reducing clinical signs and symptoms like itching, scaling and erythema. The literature evidence for this drug is Agasthiyar paripooranam -400 which is well-known Shasthric preparation In this study, no adverse reactions were reported. Hence, it is concluded that the trial drugs are clinically safe. The cost of the trial medicines is low. These drugs are easily available and the dosage is also convenient. The quantitative outcome of PASI score shows there is extremely significant reduction between at the commencement and end of the treatment i.e from 53.14±10.05 and 19.08±14.05 The qualitative outcome shows there is 52.5% of cases shown good improvement, 32.5% of cases shown moderate improvement and 15% shown mild improvement. The clinical trial conducted in selected patients was very much satisfactory and the results were encouraging. From the above results the trial of herbal formulation of Parangipattai chooranam (Internal) and Sangamver Thylam (External) are well responded in the treatment of Kaalanjaga padai.
| Item Type: | Thesis (Masters) |
|---|---|
| Additional Information: | (Reg.No: 321513203) |
| Uncontrolled Keywords: | open clinical trial of siddha drugs ; Parangipattai Chooranam ; Sangamver thylam ; ; treatment ; Kaalanjagapadai Psoriasis. |
| Subjects: | AYUSH > Sirappu Maruthuvam |
| Depositing User: | Subramani R |
| Date Deposited: | 29 Dec 2018 11:12 |
| Last Modified: | 29 Dec 2018 11:12 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10256 |
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