Formulation Design Development and Evaluation of Extended Release Matrix Tablets of Trimetazidine Hydrochloride.

Saravanan, R (2014) Formulation Design Development and Evaluation of Extended Release Matrix Tablets of Trimetazidine Hydrochloride. Masters thesis, PGP College of Pharmaceutical Science and Research Institute, Namakkal, Tamil Nadu, India.

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Abstract

Oral route of drug administration is oldest and safest mode of drug administration. It posses several advantages. It does not possess the sterility problem and minimal risk of damage at the site of administration. It provides accurate dosing without assistantship of administration. In conventional oral drug delivery system, there is little or no control over release of drug, and effective concentration at the target site can be achieved by administration of grossly excessive dosage form. This kind of dosing pattern result in constantly changing, unpredictable and often sub or supra therapeutic plasma concentration, leading to marked side effects in some cases. Moreover, the rate and extent of absorption from conventional formulation may vary greatly, depending on factor such as physiochemical properties of drug, presence of excipients, various physiological factors such as presence or absence of food, pH of gastrointestinal tract, G.I. motility etc. Stability study was conducted on tablets of Batch F9 stored at 300C (Room Temperature) and 400C for one month. Tablets were evaluated for hardness, friability, invitro release profile and drug content. After one month no significant changes were observed in any of the studied parameters during the study period, thus it could be concluded that formulation was stable. It was concluded that the tablets of batch F9 had considerable swelling behaviors and in vitro drug release. Percentage drug release in 8 hr is 80.77. It was observed that tablets of batch F9 followed the Huguchi release profiles. From the above results and discussion it is concluded that formulation of Extended release matrix tablet of Trimetazidine HCL containing HPMC K-15 (19.44%) and Hypermellose (19.44%), Ethyl cellulose (19.44%) batch F9 can be taken as an ideal or optimized formulation Extended release matrix tablet for 8 hour release as it fulfills the requirements for extended release matrix tablet..

Item Type: Thesis (Masters)
Uncontrolled Keywords: Formulation; Design Development ; Evaluation; Extended Release Matrix Tablets; Trimetazidine Hydrochloride
Subjects: PHARMACY > Pharmaceutics
Depositing User: Ravindran C
Date Deposited: 05 Jul 2017 09:50
Last Modified: 05 Jul 2017 09:50
URI: http://repository-tnmgrmu.ac.in/id/eprint/1025

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