Vijayalakshmi, K (2017) Safety and Pharmacological Profile of Kalladaippu Thool. Masters thesis, National Institute of Siddha, Chennai.
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Abstract
The test drug Kalladaippu Thool was selected from the siddha literature “Anuboga vaithiya navaneetham” for its Anti-urolithiatic, Diuretic and Saluretic activities. • The test drug was prepared by the given procedure. All the ingredientswere identified and authenticated by the experts. • Review of literature in various categories was carried out Siddha aspect, botanical aspect disclosed about the drug and the disease. • The drug was subjected to analysis such as physicochemical, chemical and also instrumental analysis which provided the key ingredients present in the drug thus it accounts the efficacy of the drug • Toxicological study was made according to OECD guidelines comprising acute, sub- acute and sub chronic toxicity study. It screens the safety of the drug which attributes its utility in long time administration. • Pharmacological study was done. It revealed that the Anti-urolithiatic, Diuretic and Saluretic activities of Kalladaippu Thool in Wistar albino rat model. • Results and discussion gives the proper justifications to prove the potency of the drug. • Conclusion gives a compiled form of the study and explains the synergistic effect of all the key ingredients and activities that supports the study. • Thus the herbo-mineral formulation Kalladaippu Thool is validated for its safety and efficacy for treating Kalladaippu and it would be a great drug of choice. CONCLUSION: From the literature evidence, physicochemical analysis, chemical analysis, Toxicological evaluation and Pharmacological studies, the drug Kalladaippu Thool have anti- urolithiatic, diuretic and saluretic activity. It was concluded that the Kalladaippu Thool can be used in the management of Kalladaippu (Urolithiasis).
| Item Type: | Thesis (Masters) |
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| Additional Information: | Reg.No.321412206 |
| Uncontrolled Keywords: | Safety ; Pharmacological Profile ; Kalladaippu Thool. |
| Subjects: | AYUSH > Gunapadam |
| Depositing User: | Subramani R |
| Date Deposited: | 29 Dec 2018 13:34 |
| Last Modified: | 29 Dec 2018 13:34 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10236 |
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