Semalatha, S (2018) Scientific Validation of Anti-cancer, Anti tumour and Anti-oxidant activities of Siddha Herbo-mineral Formulation Bhramasthiram in Various cell lines studies. Masters thesis, Government Siddha Medical College, Chennai.
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Abstract
Trial drug Bhramasthiram was selected from the classic literature “The pharmacopeia of Siddha Research Medicines” written by Dr.M.Shanmugavelu, L.I.M.,H.P.I.M. for its anti-cancer, anti-tumour, anti-oxidant activities. The dissertation started with an introduction explaining about the Siddha concept, prevalence of cervical, oral cancer and role of the test drug in treating cervical, oral cancer. The ingredients of the test drug was identified and authenticated by siddha experts. The drug was prepared as per the procedure and subjected to various studies to reveal its potency and effectiveness against the disease. The physico chemical shows potency of the Bhramasthiram. The biochemical analysis reveals the presence of chloride, Nitrate, Potassium, Calcium, Sodium, Iron, Zinc, Copper, Mercur.Thus from these results we come to know the effectiveness of the drug is due to the presence of these constituents and it has a synergistic effect in acting against the disease. The FTIR analysis construe the result that showed the presence of functional groups like alcohol, alkanes, esters, aromatics amines which might be responsible for the presence of anti-cancer action of the drug. SEM picture described its morphology and the particle size. • Toxicological study was made according to OECD guidelines comprising both acute and repeated oral dose 28days toxicity studies in wistar albino rats. It showed the safety of the drug which attributes its utility in long time administration. • Pharmacological studies were completed. It revealed the anti-cancer, anti-tumor and anti-oxidant activities of Bhramasthiram. • Results and discussion gives the essential validations to prove the potency of the drug. • Conclusion gives a Compiled form of the study and explains the synergistic effect of all the key ingredients and activities that supports the study.
| Item Type: | Thesis (Masters) |
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| Uncontrolled Keywords: | Scientific Validation ; Anti-cancer ; Anti tumour ; Anti-oxidant activities ; Siddha Herbo-mineral Formulation ; Bhramasthiram ; Various cell lines studies. |
| Subjects: | AYUSH > Gunapadam |
| Depositing User: | Subramani R |
| Date Deposited: | 29 Dec 2018 13:35 |
| Last Modified: | 29 Dec 2018 13:35 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10235 |
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