Kiruthika, B (2018) Preclinical validation of the possible mechanisms of Anti-Hypertensive, Diuretic and Anti-oxidant Activity of Venthamaraiyathi Chooranam in Rodents. Masters thesis, Government Siddha Medical College, Chennai.
|
Text
320201518kiruthika.pdf Download (22MB) | Preview |
Abstract
The trial drug Venthamaraiyathi Chooranam was selected from the siddha literature “Pharmacopoeia of Hospital of Indian Medicine” authored by Dr.Narayanaswami for Anti-hypertensive, Diuretic, Anti-oxidant activities. The dissertation started with an introduction explaining about the siddha concept, prevalence of hypertension and role of the test drug in treating hypertension, ➢ The test drug was prepared properly by the given procedure. All the ingredients were identified and authenticated by the experts. ➢ Review of literature in various categories was carried out. Siddha aspect, botanical aspect and pharmaceutical review disclosed about the drug and the disease. Pharmacological review was done to establish the methodologies. ➢ The drug was subjected to analysis such as organoleptic characters, physicochemical, phytochemical, biochemical and also instrumental analysis which provided the key ingredients present in the drug thus it accounts the efficacy of the drug ➢ Toxicological study was made according to OECD guidelines comprising both acute and sub-acute toxicity study. It showed the safety of the drug which attributes its utility in long time administration. ➢ Pharmacological study was done. It revealed the Anti-hypertensive, Diuretic and Anti-oxidant activity (In–vitro model) of Venthamaraiyathi Chooranam in spontaneously hypertensive rat model. ➢ Results and discussion gives the necessary justifications to prove the potency of the drug. ➢ Conclusion gives a compiled form of the study and explains the synergistic effect of all the key ingredients and activities that supports the study. ➢ Thus, the Polyherbal formulation venthamaraiyathi chooranam is validated for its safety and efficacy for treating hypertension and it would be a one of the drugs of choice.
| Item Type: | Thesis (Masters) |
|---|---|
| Uncontrolled Keywords: | Preclinical validation ; possible mechanisms ; Anti-Hypertensive ; Diuretic and Anti-oxidant Activity ; Venthamaraiyathi Chooranam ; Rodents. |
| Subjects: | AYUSH > Gunapadam |
| Depositing User: | Subramani R |
| Date Deposited: | 29 Dec 2018 13:36 |
| Last Modified: | 29 Dec 2018 13:36 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10233 |
Actions (login required)
 |
View Item |
