Malaichamy, P (2018) An Open clinical trial of siddha herbal formulation Thathu Viruthi Kuligai (Internal) in the treatment of Aan Maladu (Male Infertility). Masters thesis, National Institute of Siddha, Chennai.
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Abstract
The main aim of this study is to document the effectiveness of siddha medicine Thathu Viruthi Kuligai (Internal medicine) in the management of AAN MALADU (Male infertility). The objective of this study is the Clinical studies conducted in 40 cases. The raw drug was purchased from reputed country medical shop in Chennai and drug authentication by Assisstant Professor of Medicinal Botany. The drug was prepared as per standard operating procedure mentioned in the siddha literature in Gunapadam laboratory of National Institute of Siddha. The standardization of study drug was carried out in the Biochemistry lab of NIS. It revealed the presence of chloride, fluoride, carbonate with the study drug. The clinical study was conducted with a well-defined protocol and a proper proforma after getting the approval of the Institutional Ethical Committee. (IEC NO.2016/11-04/14.10.2016]. The study data were registered in CTRI (Clinical Trial Registry of India) with ID NO: CTRI/2018/01/011580. After screening 60 cases study based on the inclusion criteria and exclusion criteria reporting at the OPD of Maruthuvam, 40 cases were selected for induction to the study. Before enrollment into the trial the informed consent was obtained from the patients. The aim of the study is to increase the sperm count and sperm motility in male infertility patients. The duration of administration of study drug 48 days. The study drug dose was illanthai kottai alavu [325mg] twice a daily with cow milk Before Starting the treatment semen analysis, routine blood and urine examination were taken in all 40 patients. Siddha methods like three Humor, Thegi, Kosangal, udalthathukkal, Envagaithervu, neeikuri, nerkuri and buoyancy of Semen on water were analysed in all 40 Cases. Patients were instructed to come for clinical assessment once in 15 days. They were also instructed to bring back the unconsumed drug during the next visit and return the same. In every visit the clinical assessment was made. At the end of the treatment reduction of clinical symptoms and improvement in clinical lab para meters (Sperm count and motility) in all the 40 patients. 72.5% of patients improved after treatment more than 30 Million in sperm count. 24% of the patients were presenting increase of Active Motility with range of 50%-70%. 41% of the patients were presenting increase of Active Motility with range of 50% to 60%.10% of the patients were presenting increase of Active Motility with range of with 50%. 25% of the patients were presenting with range of Active Motility with less than 50%. The cost of medicine is comparatively low. The ingredients were easily available and the rural people will be benefited more. The mean + Standard deviation of sperm count before and after treatment were 21.01 and 60.6 respectively which is statistically significant (t=4.63 P < 1.0000. The mean + Standard deviation of sperm motility before and after treatment were 23.25 and 36.75 respectively which is statistically significant (t=5.04 P < 1.0000. I have concluded the siddha medicine thathuviruthikulikai was effective in treatment of Aan maladu‖ (Male infertility especially oligospermia and asthenozoospermia).
| Item Type: | Thesis (Masters) |
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| Additional Information: | (Reg No: 321511205) |
| Uncontrolled Keywords: | Thathu Viruthi Kuligai ; Aanmaladu ; Male Infertility ; Open clinical trial ; siddha herbal formulation. |
| Subjects: | AYUSH > Maruthuvam |
| Depositing User: | Subramani R |
| Date Deposited: | 29 Dec 2018 13:49 |
| Last Modified: | 29 Dec 2018 13:51 |
| URI: | http://repository-tnmgrmu.ac.in/id/eprint/10225 |
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