An Open Non Randomized Clinical Trial of Perungaya Chooranam in Madhumegam (Diabetes Mellitus Type-II)

Nithya, K (2018) An Open Non Randomized Clinical Trial of Perungaya Chooranam in Madhumegam (Diabetes Mellitus Type-II). Masters thesis, Government Siddha Medical College, Chennai.


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The clinical study on Madhumegam was carried out in the Post Graduate Department of Maruthuvam, Government Siddha Medical College, Arignar Anna Hospital, Chennai-106, during the period of 2016 - 2018. A total of 40 patients were treated in the Out Patient Department (OPD). The clinical and pathological assessment was carried out on the basis of both Siddha and Modern aspects. All the 40 patients were treated with Perungaya Chooranam, 2g BD with lukewarm water for 90 days. The responses were assessed once in 7 days for all the patients. • The peak incidence of Madhumegam was in the age group of 51-60 yrs (45%) in both sexes. • The prevalence was higher among the lower income (47.5%). • The disease is more common in housewives (40%). So high incidence occurs in women. • Regarding diet, the disease is seen among mixed dietary habits of about 80%. • Regarding family history, 52.5% had no relavent history. • Most of the patients were affected in Pitha kaalam (95%). • In Vatham - Abaanan, Viyanan, Samanan, Kirukaran and Devathathan were affected in all the cases 100%, Koorman was affected in 7 cases (17.5%). • In Pitham - Analagam and Sathagam 100%, Ranjagam 20%, Alosagam 17.5% and Prasagam 15% were affected. • In Kabam - Kilethagam 100% and Santhigam 60% were affected. • Among the Ezhu Udalthathukkal, Saaram, Seneer were 100% affected, Enbu (60%), Oon (15%), Kozhuppu (15%) were affected. • Regarding Envagaithervugal - Naa, Naadi and Moothiram were 100% affected Niram, Malam (20%), Vizhi (17.5%), Sparisam (15%) were affected. • Naadi – PithaVatha naadi (70%) was most commonly observed. • In Neikuri examination, 65% Pithaneer were observed. • The Toxicological study of Perungaya Chooranam revealed no toxicity. • The pharmacological study shows Anti Diabetic Activity in Streptozotocin induced diabetic rats. • Urine sugar Fasting and Postprandial became normal in 92.5% and 87.5% of patients respectively. • Regarding Blood sugar level, fasting and post prandial blood sugar reduced in 90% and 82.5% of the cases respectively. • HbA1C level improved in 75% of cases which shows Good control in Madhumegam. • The clinical trial shows that there is significant improvement in clinical manifestations of Madhumegam. • The Biostatistical analysis of the clinical trial shows significant p-value < 0.000 and hence the treatment was effective and significant. CONCLUSION: Madhumegam is primarily due to derangement of Pitha kutram. • The trial medicine Perungaya Chooranam predominating with Thuvarppu suvai, it neutralises the deranged Pitham by Ethirurai Maruthuvam. • Perungaya Chooranam reveals no toxicity in animal models and hence proved to be safe in human subjects. • From Preclinical Pharmacological studies, Perungaya Chooranam has Anti-Diabetic activity. • No adverse effect was reported during the clinical study. • Perungaya Chooranam significantly reduced blood sugar level and also reduced clinical features of Madhumegam. • Perungaya Chooranam is cost effective. Hence I conclude that Perungaya Chooranam will be a better Medicine that can be used in the treatment of Madhumegam.

Item Type: Thesis (Masters)
Additional Information: (Reg. No. 321511107)
Uncontrolled Keywords: Perungaya Chooranam ; Madhumegam ; Diabetes Mellitus Type II ; Open Non Randomized Clinical Trial.
Subjects: AYUSH > Maruthuvam
Depositing User: Subramani R
Date Deposited: 29 Dec 2018 13:56
Last Modified: 29 Dec 2018 13:56

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